About: Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features

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About: Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background Differences exist between the proximal and distal colon in terms of developmental origin, exposure to patterning genes, environmental mutagens and gut flora. Little is known on how these differences may affect mechanisms of tumorigenesis, side specific therapy response or prognosis. We explored systematic differences in pathway activation and their clinical implications. Materials and Methods Detailed clinico-pathological data for 3045 colon carcinoma patients enrolled in the PETACC3 adjuvant chemotherapy trial were available for analysis. A subset of 1404 samples had molecular data, including gene expression and DNA copy number profiles for 589 and 199 samples, respectively. In addition, 413 colon adenocarcinoma from TCGA collection were also analyzed. Tumor side effect on anti-EGFR therapy was assessed in a cohort of 325 metastatic patients. Outcome variables considered were relapse-free survival (RFS) and survival after relapse (SAR). Background Differences exist between the proximal and distal colon in terms of developmental origin, exposure to patterning genes, environmental mutagens and gut flora. Little is known on how these differences may affect mechanisms of tumorigenesis, side specific therapy response or prognosis. We explored systematic differences in pathway activation and their clinical implications. Materials and Methods Detailed clinico-pathological data for 3045 colon carcinoma patients enrolled in the PETACC3 adjuvant chemotherapy trial were available for analysis. A subset of 1404 samples had molecular data, including gene expression and DNA copy number profiles for 589 and 199 samples, respectively. In addition, 413 colon adenocarcinoma from TCGA collection were also analyzed. Tumor side effect on anti-EGFR therapy was assessed in a cohort of 325 metastatic patients. Outcome variables considered were relapse-free survival (RFS) and survival after relapse (SAR). (en)
Title	Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features (en)
skos:prefLabel	Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features (en)
skos:notation	RIV/00216224:14110/14:00076812!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Popovici, Vlad Budinská, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	11788
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00076812
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Colon cancer; Expression profiling; Mutations; Oncogenic pathways; Survival (en)
http://linked.open.../riv/klicoveSlovo	Expression profiling Oncogenic pathways Mutations Survival Colon cancer
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3BACFF87BB4B]
http://linked.open...i/riv/nazevZdroje	Annals of Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Budinská, Eva Popovici, Vlad Roth, Arnaud Bosman, F.T. Delorenzi, M. Di Narzo, A. F. D´Ario, G. Gerster, S. Jacobs, B. Klingbiel, D. Missiaglia, E. Soneson, C. Tejpar, S. Vecchione, L. Yan, P.
http://linked.open...ain/vavai/riv/wos	000343045500017
issn	0923-7534
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/annonc/mdu275
http://localhost/t...ganizacniJednotka	14110

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