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  • Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome.
  • Metabolic syndrome, a condition increasing cardiovascular morbidity, mortality and risk for diabetes mellitus type 2, is currently worldwide reaching epidemic proportions. This complex disorder represents an urgent challenge for new pharmacotherapeutic strategies formulation. Pathophysiological mechanisms underlying metabolic syndrome are not completely understood, nevertheless growing evidence is supporting the hypothesis that multiple metabolic dysregulations do contribute to its development. A potential target for pharmacological intervention is considered to be dysregulation of adipose tissue endocrine/paracrine function. Specific adipokines, proteins secreted by the adipose tissue, with some pleiotropic effects, have been identified with strong association to regulation of energy metabolism, appetite, insulin signaling, tissue insulin sensitivity and the proinflammatory state related to metabolic syndrome. (en)
Title
  • Metabolic syndrome – dysregulation of adipose tissue endocrine function
  • Metabolic syndrome – dysregulation of adipose tissue endocrine function (en)
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  • Metabolic syndrome – dysregulation of adipose tissue endocrine function
  • Metabolic syndrome – dysregulation of adipose tissue endocrine function (en)
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  • RIV/00216224:14110/14:00076563!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • P(ED1.1.00/02.0068), S, V
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  • 4
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  • 28528
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  • RIV/00216224:14110/14:00076563
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  • metabolic syndrome; insulin resistance; adipose tissue; adipokines (en)
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  • CZ - Česká republika
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  • [B160E37872EA]
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  • Česká a slovenská farmacie
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  • 63
http://linked.open...iv/tvurceVysledku
  • Kučerová, Jana
  • Suchý, Pavel
  • Horská, Kateřina
  • Kotolová, Hana
issn
  • 1210-7816
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  • 14110
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