About: Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation

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About: Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has been recently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI). It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemical processes. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has been recently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI). (en)
Title	Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation (en)
skos:prefLabel	Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation (en)
skos:notation	RIV/00216224:14110/14:00076387!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.100/02/0123), S
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Jurajda, Michal Pařenica, Jiří Vašků, Anna Bienertová-Vašků, Julie Pávková Goldbergová, Monika Šplíchal, Zbyněk Lipková, Jolana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	36198
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00076387
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Circadian clock; Per3 VNTR polymorphism; cosinor analysis; heart failure; myocardial infarction (en)
http://linked.open.../riv/klicoveSlovo	Circadian clock Per3 VNTR polymorphism heart failure cosinor analysis myocardial infarction
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3E414ED8AECB]
http://linked.open...i/riv/nazevZdroje	Chronobiology International
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Bienertová Vašků, Julie Jurajda, Michal Pařenica, Jiří Vašků, Anna Lipková, Jolana Pávková Goldbergová, Monika Šplíchal, Zbyněk
http://linked.open...ain/vavai/riv/wos	000341754000002
issn	0742-0528
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/07420528.2014.921790
http://localhost/t...ganizacniJednotka	14110

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