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  • The aim of this work was to retrospectively analyze patients with Philadelphia-negative myeloproliferative neoplasms through evaluation of frequency and characteristics of second malignancies (other than acute leukaemia and myelodysplastic syndrome). Patients and Methods: Records of 172 patients were reviewed; an analysis was performed on data from 66 patients treated with hydroxyurea, 105 patients treated with other cytoreductive therapy, and 25 patients without treatment. Results: A higher occurrence of second malignancies was found in the group treated with hydroxyurea (7.6%; other cytoreduction: 1.2%; without therapy: 0). After a median follow-up of 89 months in the hydroxyurea group, 13 patients developed second cancer during hydroxyurea therapy, located on the skin (68.75%) and other sites (31.25%).
  • The aim of this work was to retrospectively analyze patients with Philadelphia-negative myeloproliferative neoplasms through evaluation of frequency and characteristics of second malignancies (other than acute leukaemia and myelodysplastic syndrome). Patients and Methods: Records of 172 patients were reviewed; an analysis was performed on data from 66 patients treated with hydroxyurea, 105 patients treated with other cytoreductive therapy, and 25 patients without treatment. Results: A higher occurrence of second malignancies was found in the group treated with hydroxyurea (7.6%; other cytoreduction: 1.2%; without therapy: 0). After a median follow-up of 89 months in the hydroxyurea group, 13 patients developed second cancer during hydroxyurea therapy, located on the skin (68.75%) and other sites (31.25%). (en)
Title
  • Second Malignancies in Philadelphia-negative Myeloproliferative Neoplasms–Single-center Experience
  • Second Malignancies in Philadelphia-negative Myeloproliferative Neoplasms–Single-center Experience (en)
skos:prefLabel
  • Second Malignancies in Philadelphia-negative Myeloproliferative Neoplasms–Single-center Experience
  • Second Malignancies in Philadelphia-negative Myeloproliferative Neoplasms–Single-center Experience (en)
skos:notation
  • RIV/00216224:14110/14:00075664!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 44132
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/14:00075664
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Second malignancies; hydroxyurea; myeloproliferative neoplasm; skin cancer (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GR - Řecká republika
http://linked.open...ontrolniKodProRIV
  • [6119B2E3A9D4]
http://linked.open...i/riv/nazevZdroje
  • ANTICANCER RESEARCH
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 34
http://linked.open...iv/tvurceVysledku
  • Kiss, Igor
  • Kissová, Jarmila
  • Ovesná, Petra
  • Penka, Miroslav
  • Buliková, Alena
http://linked.open...ain/vavai/riv/wos
  • 000335545900059
issn
  • 0250-7005
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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