About: TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo

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About: TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, though its function has not been characterized. TUSC3 shares homologies with the yeast oligosaccharyltransferase (OST) complex subunit Ost3p, suggesting a role in protein glycosylation. We provide evidence that TUSC3 is part of the OST complex and affects N-linked glycosylation in mammalian cells. Loss of TUSC3 expression in DU145 and PC3 prostate cancer cell lines leads to increased proliferation, migration and invasion as well as accelerated xenograft growth in a PTEN negative background. TUSC3 downregulation also affects endoplasmic reticulum (ER) structure and stress response, which results in increased Akt signaling. Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular. Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, though its function has not been characterized. TUSC3 shares homologies with the yeast oligosaccharyltransferase (OST) complex subunit Ost3p, suggesting a role in protein glycosylation. We provide evidence that TUSC3 is part of the OST complex and affects N-linked glycosylation in mammalian cells. Loss of TUSC3 expression in DU145 and PC3 prostate cancer cell lines leads to increased proliferation, migration and invasion as well as accelerated xenograft growth in a PTEN negative background. TUSC3 downregulation also affects endoplasmic reticulum (ER) structure and stress response, which results in increased Akt signaling. Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular. (en)
Title	TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo (en)
skos:prefLabel	TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo (en)
skos:notation	RIV/00216224:14110/14:00075600!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7AMB12AT019)
http://linked.open...iv/cisloPeriodika	%223739%22
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Vaňhara, Petr Kratochvílová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	51428
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00075600
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	POSTTRANSLATIONAL N-GLYCOSYLATION; RECESSIVE MENTAL-RETARDATION; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; XBP1 MESSENGER-RNA; CHROMOSOME ARM 8P; OVARIAN-CANCER; OLIGOSACCHARYLTRANSFERASE; DELETION; GENE (en)
http://linked.open.../riv/klicoveSlovo	GENE OVARIAN-CANCER DELETION CHROMOSOME ARM 8P ENDOPLASMIC-RETICULUM STRESS OLIGOSACCHARYLTRANSFERASE POSTTRANSLATIONAL N-GLYCOSYLATION RECESSIVE MENTAL-RETARDATION UNFOLDED PROTEIN RESPONSE XBP1 MESSENGER-RNA
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CD29850B0B6A]
http://linked.open...i/riv/nazevZdroje	Scientific Reports
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of novel tumor markers in ovarian and prostate cancers
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Vaňhara, Petr Anees, Mariam Horak, Peter Krainer, Michael Pils, Dietmar Kratochvílová, Kateřina Gerschpacher, Marion Horvat, Reinhard Lemberger, Christof E. Marhold, Maximilian Sibilia, Maria Tomasich, Erwin
http://linked.open...ain/vavai/riv/wos	000329849100005
issn	2045-2322
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/srep03739
http://localhost/t...ganizacniJednotka	14110

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