About: Strategies to manage hepatitis C virus (HCV) disease burden

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. (en)
Title	Strategies to manage hepatitis C virus (HCV) disease burden Strategies to manage hepatitis C virus (HCV) disease burden (en)
skos:prefLabel	Strategies to manage hepatitis C virus (HCV) disease burden Strategies to manage hepatitis C virus (HCV) disease burden (en)
skos:notation	RIV/00216224:14110/14:00075456!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I V
http://linked.open...avai/riv/aktivity	I, V
http://linked.open...iv/cisloPeriodika	Supplement 1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Husa, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	47662
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00075456
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diagnosis; epidemiology; HCV; mortality; treatment; scenarios; prevalence; incidence; hepatitis C; disease burden (en)
http://linked.open.../riv/klicoveSlovo	scenarios diagnosis epidemiology mortality prevalence treatment HCV hepatitis C incidence disease burden
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[163439FA7C2C]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF VIRAL HEPATITIS
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	93 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Buti, M. Cornberg, M. Husa, Petr … Moreno, C. Akarca, U. Balik, I. Berg, T. Bihl, F. Bilodeau, M. Blasco, A. J. Bruggmann, P. Calinas, F. Calleja, J. L. Cheinquer, H. Christensen, P. B. Clausen, M. Coelho, H. S. M. Correa, M. C. Mendes Cramp, M. E. Dore, G. J. Doss, W. Duberg, A. S. El-Sayed, M. H. Ergör, G. Esmat, G. Estes, C. Falconer, K. Ferraz, M. L. G. Ferreira, P. R. Frankova, S. Félix, J. García-Samaniego, J. Gerstoft, J. Giria, J. A. Gonçales, F. L. Jr. Gschwantler, M. Hofer, H. Hézode, C. Idilman, R. Kaita, K. D. E. Kautz, A. Kaymakoglu, S. Krajden, M. Krarup, H. Kåberg, M. Laleman, W. Lavanchy, D. Lázaro, P. Marinho, R. T. Marotta, P. Mauss, S. Mello, C. E. Brandão Myers, R. P. Müllhaupt, B. Nemecek, V. Parkes, J. Peltekian, K. M. Pessôa, M. Guimarães Ramji, A.

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