About: LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Quaternary benzo[c]phenantridine alkaloids (QBAs) belong to a subgroup of isoquinoline alkaloids. They include major sanguinarine (SA) and chelerythrine (CHE) as well as minor QBAs chelirubine (CR), sanguilutine (SL), sanguirubine (SR), chelilutine (CL), and macarpine (MA). The effects of QBAs on biological systems have been studied extensively, especially for commercially available SA and CHE. Limited availability of the minor pentasubstituted QBAs and hexasubstituted MA reduces data concerning their biological effects. Although the QBA molecular structures are very similar, the mechanism of their action on the molecular level may be different. As pharmacological studies imply that even a small change in the structure may trigger a significant difference in pharmacological activity, it cannot be simply accepted that metabolic routes of all QBAs will be analogous. Quaternary benzo[c]phenantridine alkaloids (QBAs) belong to a subgroup of isoquinoline alkaloids. They include major sanguinarine (SA) and chelerythrine (CHE) as well as minor QBAs chelirubine (CR), sanguilutine (SL), sanguirubine (SR), chelilutine (CL), and macarpine (MA). The effects of QBAs on biological systems have been studied extensively, especially for commercially available SA and CHE. Limited availability of the minor pentasubstituted QBAs and hexasubstituted MA reduces data concerning their biological effects. Although the QBA molecular structures are very similar, the mechanism of their action on the molecular level may be different. As pharmacological studies imply that even a small change in the structure may trigger a significant difference in pharmacological activity, it cannot be simply accepted that metabolic routes of all QBAs will be analogous. (en)
Title	LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES (en)
skos:prefLabel	LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES LIQUID CHROMATOGRAPHY MASS SPECTROMETRY OF SELECTED BENZOPHENANTHRIDINE ALKALOIDS INCUBATED WITH RAT LIVER MICROSOMES (en)
skos:notation	RIV/00216224:14110/13:00070341!RIV14-MSM-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(LH12176), S
http://linked.open...iv/cisloPeriodika	Special Issue, Supplement 3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Midlik, Adam Dovrtělová, Gabriela Nosková, Kristýna Kušnyerová, Ivana Táborská, Eva Juřica, Jan Peš, Ondřej Pěnčíková, Kristýna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	85066
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00070341
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	LC MS; QBA; benzophenanthridine; rat liver microsomes; metabolite (en)
http://linked.open.../riv/klicoveSlovo	LC MS benzophenanthridine rat liver microsomes metabolite QBA
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[47B48A0CC61D]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Benzophenanthridine alkaloids - study of their effects on cellular and molecular level
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	107
http://linked.open...iv/tvurceVysledku	Juřica, Jan Táborská, Eva Peš, Ondřej Pěnčíková, Kristýna Dovrtělová, Gabriela Kušnyerová, Ivana Midlik, Adam Nosková, Kristýna
http://linked.open...ain/vavai/riv/wos	000328730800049
issn	0009-2770
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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