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  • This work provides a review of immune reactions involved in classic as well as alternative methods of peripheral nerve regeneration, and mainly with a view to understanding their beneficial effects. Axonal degeneration distal to nerve damage triggers a cascade of inflammatory events alongside injured nerve fibers known as Wallerian degeneration (WD). The early inflammatory reactions of WD comprise the complement system, arachidonic acid metabolites, and inflammatory mediators that are related to myelin fragmentation and activation of Schwann cells. Fine-tuned upregulation of the cytokine/chemokine network by Schwann cells activates resident and hematogenous macrophages to complete the clearance of axonal and myelin debris and stimulate regrowth of axonal sprouts. In addition to local effects, immune reactions of neuronal bodies and glial cells are also implicated in the survival and conditioning of neurons to regenerate severed nerves.
  • This work provides a review of immune reactions involved in classic as well as alternative methods of peripheral nerve regeneration, and mainly with a view to understanding their beneficial effects. Axonal degeneration distal to nerve damage triggers a cascade of inflammatory events alongside injured nerve fibers known as Wallerian degeneration (WD). The early inflammatory reactions of WD comprise the complement system, arachidonic acid metabolites, and inflammatory mediators that are related to myelin fragmentation and activation of Schwann cells. Fine-tuned upregulation of the cytokine/chemokine network by Schwann cells activates resident and hematogenous macrophages to complete the clearance of axonal and myelin debris and stimulate regrowth of axonal sprouts. In addition to local effects, immune reactions of neuronal bodies and glial cells are also implicated in the survival and conditioning of neurons to regenerate severed nerves. (en)
Title
  • Role of Inflammation and Cytokines in Peripheral Nerve Regeneration
  • Role of Inflammation and Cytokines in Peripheral Nerve Regeneration (en)
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  • Role of Inflammation and Cytokines in Peripheral Nerve Regeneration
  • Role of Inflammation and Cytokines in Peripheral Nerve Regeneration (en)
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  • RIV/00216224:14110/13:00069762!RIV14-MSM-14110___
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
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  • P(ED1.1.00/02.0068)
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  • 1
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  • 103323
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  • RIV/00216224:14110/13:00069762
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  • Wallerian degeneration; Neuroinflammation; Immune cells; Inflammatory mediators; Cytokines; Axonal regeneration (en)
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  • US - Spojené státy americké
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  • [DCE56130BD11]
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  • International Review of Neurobiology
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  • 108
http://linked.open...iv/tvurceVysledku
  • Dubový, Petr
  • Jančálek, Radim
  • Kubek, Tomáš
http://linked.open...ain/vavai/riv/wos
  • 000327359900008
issn
  • 0074-7742
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/B978-0-12-410499-0.00007-1
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  • 14110
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