About: Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases

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About: Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e. Tumor growth and cancer development are considered clear examples of Darwinian selection, whereby random mutational events in heterogeneous cancer cell populations that best fit the selective microenvironment are preferred.1 As a result, cancer cells evolve resistance to apoptosis, hide from immune surveillance and acquire the ability to invade other organs. Cancer cells, however, are not necessarily passive subjects of selection; they can actively subvert the host tissue to provide a favorable habitat for their growth. Recent findings by Calon et al. convincingly demonstrate that transforming growth factor-b-induced secretion of interleukin 11 by tumor stromal fibroblasts is a necessary prerequisite for the development of distant metastases in colorectal carcinoma. Thus, understanding the complex molecular feedback loops between cancer cells and the surrounding microenvironment (i.e. (en)
Title	Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases (en)
skos:prefLabel	Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases Mutual cytokine crosstalk between colon cancer cells and microenvironment initiates development of distant metastases (en)
skos:notation	RIV/00216224:14110/13:00067733!RIV14-MSM-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(7AMB12AT019), P(ED1.100/02/0123)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vaňhara, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	90247
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00067733
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metastasis; transforming growth factor-b; interleukin 11; metastatic niche; tumor stroma; dissemination; microenvironment (en)
http://linked.open.../riv/klicoveSlovo	interleukin 11 metastatic niche transforming growth factor-b tumor stroma dissemination metastasis microenvironment
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1FBD70BE44FE]
http://linked.open...i/riv/nazevZdroje	JAK-STAT
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of novel tumor markers in ovarian and prostate cancers St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Souček, Karel Vaňhara, Petr
issn	2162-3996
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.4161/jkst.23810
http://localhost/t...ganizacniJednotka	14110

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