About: Dendritic cells and their role in tumor immunosurveillance

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the review we discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis. Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the review we discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis. (en)
Title	Dendritic cells and their role in tumor immunosurveillance Dendritic cells and their role in tumor immunosurveillance (en)
skos:prefLabel	Dendritic cells and their role in tumor immunosurveillance Dendritic cells and their role in tumor immunosurveillance (en)
skos:notation	RIV/00216224:14110/13:00065766!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT11137)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Michálek, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	68361
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065766
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Dendritic cell biology; immunogenic and tolerogenic dendritic cells; killer dendritic cells; tumor immunosurveillance; immunosuppression; vascular leukocytes (en)
http://linked.open.../riv/klicoveSlovo	Dendritic cell biology immunogenic and tolerogenic dendritic cells killer dendritic cells tumor immunosurveillance vascular leukocytes immunosuppression
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C5F2F30D43C4]
http://linked.open...i/riv/nazevZdroje	Journal of Innate Immunity
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Anti-tumour therapy - vaccination with dendritic cells in patients with metastatic renal cell carcinoma. Phase II clinical study.
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Michálek, Jaroslav Strioga, Marius Dobrovolskiene, Neringa Pasukoniene, Vita Powell, Daniel J Jr Schijns, Virgil
http://linked.open...ain/vavai/riv/wos	000313592100010
issn	1753-4259
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1753425912449549
http://localhost/t...ganizacniJednotka	14110

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