About: Apolipoprotein E gene polymorphisms in chronic periodontitis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Objective: Periodontal diseases can be related to common systemic conditions, and, as recently described, alterations in blood lipid levels. The aim of this study was to analyze two apolipoprotein E (ApoE) gene polymorphisms in patients with chronic periodontitis (CP) in relation to periodontopathic bacteria and lipid levels. Methods: 469 unrelated subjects were included in this case-control study. Genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method monitored by SYBR Green, for ApoE (rs429358 and rs7412) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray based on a periodontal pathogen detection kit and lipid levels were measured in a subgroup of subjects. Results: There was no evidence for a significant association between ApoE gene polymorphisms and CP (E2/E2 vs. E3/E3: OR=0.63, 95%CI=0.12-3.15; E2/E3 vs. E3/E3: OR=1.61, 95%CI=0.84-3.11; E2/E4 vs. Objective: Periodontal diseases can be related to common systemic conditions, and, as recently described, alterations in blood lipid levels. The aim of this study was to analyze two apolipoprotein E (ApoE) gene polymorphisms in patients with chronic periodontitis (CP) in relation to periodontopathic bacteria and lipid levels. Methods: 469 unrelated subjects were included in this case-control study. Genomic DNA of 294 patients with CP and 175 healthy/non-periodontitis controls were genotyped, using the real-time polymerase chain reaction (RT-PCR) method monitored by SYBR Green, for ApoE (rs429358 and rs7412) gene polymorphisms. Subgingival bacterial colonization was investigated by the DNA-microarray based on a periodontal pathogen detection kit and lipid levels were measured in a subgroup of subjects. Results: There was no evidence for a significant association between ApoE gene polymorphisms and CP (E2/E2 vs. E3/E3: OR=0.63, 95%CI=0.12-3.15; E2/E3 vs. E3/E3: OR=1.61, 95%CI=0.84-3.11; E2/E4 vs. (en)
Title	Apolipoprotein E gene polymorphisms in chronic periodontitis Apolipoprotein E gene polymorphisms in chronic periodontitis (en)
skos:prefLabel	Apolipoprotein E gene polymorphisms in chronic periodontitis Apolipoprotein E gene polymorphisms in chronic periodontitis (en)
skos:notation	RIV/00216224:14110/13:00065618!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT11405)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Izakovičová-Hollá, Lydie Bořilová Linhartová, Petra Bártová, Jiřina Vokurka, Jan Fassmann, Antonín Poskerová, Hana Máchal, Jan
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	61647
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065618
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ApoE; chronic periodontitis; gene polymorphism; microbial colonization (en)
http://linked.open.../riv/klicoveSlovo	gene polymorphism ApoE chronic periodontitis microbial colonization
http://linked.open...ontrolniKodProRIV	[2AAE6DFDC584]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Microbiologic and genetic determinants of the onset and progression of periodontitis in type 1 and 2 diabetics and their reciprocal relationship to diabetes compensation
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Izakovičová-Hollá, Lydie Vokurka, Jan Fassmann, Antonín Poskerová, Hana Máchal, Jan Bořilová Linhartová, Petra Bártová, Jiřina
http://localhost/t...ganizacniJednotka	14110

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