About: ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography

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About: ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). Methods: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5-exonuclease (Taqman) chemistry on the ABI Prism 7000 system (Applied Biosystems, Foster City, CA, USA). Results: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81 higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). The objective of this research was to determine whether invasively measured central pulse pressure (PP) in patients indicated for coronarography is associated with two common polymorphisms in the ACE2 region (rs4646156 and rs4646174). Methods: A total of 307 patients were enrolled in the study. The genotyping of both SNPs from peripheral blood samples was carried out using 5-exonuclease (Taqman) chemistry on the ABI Prism 7000 system (Applied Biosystems, Foster City, CA, USA). Results: In both polymorphisms, the associations with central PP were found to be highly significant when all five possible genotypes in the population had been compared (p = 0.0001). In men, there was a higher incidence of previous myocardial infarction in G0 genotype carriers of rs54646174 (OR ratio = 7; p = 0.005). The AA genotype of rs4646156 had a 7.81 higher risk of severe angina pectoris in women (OR = 7.81, p = 0.05). (en)
Title	ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography (en)
skos:prefLabel	ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography ACE2 gene polymorphisms and invasively measured central pulse pressure in cardiac patients indicated for coronarography (en)
skos:notation	RIV/00216224:14110/13:00065567!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS10206)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Pařenica, Jiří Zlámal, Filip Kala, Petr Vašků, Anna Bienertová-Vašků, Julie Špinar, Jindřich Pávková Goldbergová, Monika Lipková, Jolana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	59336
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065567
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ACE2; polymorphism; pulse pressure; severity (en)
http://linked.open.../riv/klicoveSlovo	ACE2 polymorphism severity pulse pressure
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EA8186480B74]
http://linked.open...i/riv/nazevZdroje	Journal of the Renin-Angiotensin-Aldosterone System
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Association of polymorphisms in genes for matrix metalloproteinases, their inhibitors, ACE and ACE2 with central pulse pressure in cardiovascular patients
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Bienertová Vašků, Julie Kala, Petr Pařenica, Jiří Vašků, Anna Zlámal, Filip Špinar, Jindřich Lipková, Jolana Pávková Goldbergová, Monika
http://linked.open...ain/vavai/riv/wos	000323207100005
issn	1470-3203
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1470320312460291
http://localhost/t...ganizacniJednotka	14110

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