About: Caveolin-1 as a potential high-risk prostate cancer biomarker

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Current diagnostic techniques of prostate cancer cannot efficiently distinguish the latent and low-risk forms from the high-risk significant forms of prostate cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved in metastatic processes. It has also been shown that Cav-1 expression is induced under stress conditions, such as oxidative stress. The present study focused on the determination of prognostic markers of aggressive (high-grade) forms of prostate cancer. We determined serum Cav-1 and serum markers of antioxidant activity-glutathione (GSH), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP), N,N-dimethyl-1,4-diaminobenzene (DMPD), free radicals method (FRK) and blue chromium peroxide (Cro) in 97 serum samples (82 prostate cancer patients and 15 controls). Current diagnostic techniques of prostate cancer cannot efficiently distinguish the latent and low-risk forms from the high-risk significant forms of prostate cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved in metastatic processes. It has also been shown that Cav-1 expression is induced under stress conditions, such as oxidative stress. The present study focused on the determination of prognostic markers of aggressive (high-grade) forms of prostate cancer. We determined serum Cav-1 and serum markers of antioxidant activity-glutathione (GSH), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP), N,N-dimethyl-1,4-diaminobenzene (DMPD), free radicals method (FRK) and blue chromium peroxide (Cro) in 97 serum samples (82 prostate cancer patients and 15 controls). (en)
Title	Caveolin-1 as a potential high-risk prostate cancer biomarker Caveolin-1 as a potential high-risk prostate cancer biomarker (en)
skos:prefLabel	Caveolin-1 as a potential high-risk prostate cancer biomarker Caveolin-1 as a potential high-risk prostate cancer biomarker (en)
skos:notation	RIV/00216224:14110/12:00064830!RIV13-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(NS10200), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Gumulec, Jaromír Sztalmachová, Markéta Masařík, Michal Hlavna, Marián
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	126150
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/12:00064830
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	prostate cancer; tumour marker; prognostic marker; immunodetection; electrochemistry; polymerase chain reaction; molecular biology techniques (en)
http://linked.open.../riv/klicoveSlovo	polymerase chain reaction molecular biology techniques prognostic marker prostate cancer tumour marker electrochemistry immunodetection
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[52C386D975C1]
http://linked.open...i/riv/nazevZdroje	Oncology Reports
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Tumor markers, their determination and correlation with prostate carcinoma
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Eckschlager, Tomáš Gumulec, Jaromír Hrabec, Roman Kizek, René Křížková, Soňa Masařík, Michal Rovný, Arne Sochor, Jiří Sztalmachová, Markéta Hlavna, Marián
http://linked.open...ain/vavai/riv/wos	000300118700033
issn	1021-335X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.3892/or.2011.1587
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Caveolin-1 as a potential high-risk prostate cancer biomarker

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