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  • Diabetes mellitus (DM) is a heterogeneous syndrome which is marked by hyperglycemy, insulin effect deficiency (absolute or relative), simultaneous changes of metabolism of lipides and proteins and an inclination to development of chronical and acute complications. In gerontology it is clinically the most frequent and extremely serious metabolic disorder. Senior patients suffer predominantly from DM of the type 2 (70+ up to 95%). DM 2 development is caused mainly by 1. insuline resistance; 2. Impaired insulin secretion; 3. Impaired gluconeogenesis supression. DM2 in advanced age stems from an interaction of genetic predisposition and an environmental influence. Of particular importance are nutritional habits, modern lifestyle, stress and minor physical activity. Clinical manifested DM2 is preceeded by insulin resistance (IR) with a decrease of insulin biological effectivity and it is generally presumed that the latent period duration is about 6-12 years without any subjective difficulties.
  • Diabetes mellitus (DM) is a heterogeneous syndrome which is marked by hyperglycemy, insulin effect deficiency (absolute or relative), simultaneous changes of metabolism of lipides and proteins and an inclination to development of chronical and acute complications. In gerontology it is clinically the most frequent and extremely serious metabolic disorder. Senior patients suffer predominantly from DM of the type 2 (70+ up to 95%). DM 2 development is caused mainly by 1. insuline resistance; 2. Impaired insulin secretion; 3. Impaired gluconeogenesis supression. DM2 in advanced age stems from an interaction of genetic predisposition and an environmental influence. Of particular importance are nutritional habits, modern lifestyle, stress and minor physical activity. Clinical manifested DM2 is preceeded by insulin resistance (IR) with a decrease of insulin biological effectivity and it is generally presumed that the latent period duration is about 6-12 years without any subjective difficulties. (en)
Title
  • Diabetes mellitus in advanced age – diabetologist’s and geriatrician’s view
  • Diabetes mellitus in advanced age – diabetologist’s and geriatrician’s view (en)
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  • Diabetes mellitus in advanced age – diabetologist’s and geriatrician’s view
  • Diabetes mellitus in advanced age – diabetologist’s and geriatrician’s view (en)
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  • RIV/00216224:14110/12:00063463!RIV13-MSM-14110___
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  • 130912
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  • RIV/00216224:14110/12:00063463
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  • diabetes mellitus - insulin resistance - ethiopathogenesis - diagnostic criteria - late complications - advanced age - treatment (en)
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  • [0E1A63229870]
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  • Meluzínová, Hana
  • Weber, Pavel
  • Ambrošová, Petronela
  • Canov, Petr
  • Matějovská Kubešová, Hana
  • Polcarová, Vlasta
  • Weberová, Dana
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  • 14110
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