About: CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment

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About: CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cytochrome P450, namely CYP2D6 is major metabolizing enzyme for many antipsychotics, including risperidone. The aim of present study was to evaluate in 35 patients with first episode of schizophrenia relation of genotype and phenotype of CYP2D6 to therapeutic response to risperidone treatment and occurrence of adverse effects. PANSS score was assessed weekly; as response was considered at least 30 % reduction of baseline of total PANSS score; CYP2D6 genotype was assessed by automatic sequencing of DNA isolated from peripheral leukocytes, phenotype was assessed using dextromethorphan as a probe substrate. Cytochrome P450, namely CYP2D6 is major metabolizing enzyme for many antipsychotics, including risperidone. The aim of present study was to evaluate in 35 patients with first episode of schizophrenia relation of genotype and phenotype of CYP2D6 to therapeutic response to risperidone treatment and occurrence of adverse effects. PANSS score was assessed weekly; as response was considered at least 30 % reduction of baseline of total PANSS score; CYP2D6 genotype was assessed by automatic sequencing of DNA isolated from peripheral leukocytes, phenotype was assessed using dextromethorphan as a probe substrate. (en) Cytochrome P450, namely CYP2D6 is major metabolizing enzyme for many antipsychotics, including risperidone. The aim of present study was to evaluate in 35 patients with first episode of schizophrenia relation of genotype and phenotype of CYP2D6 to therapeutic response to risperidone treatment and occurrence of adverse effects. PANSS score was assessed weekly; as response was considered at least 30 % reduction of baseline of total PANSS score; CYP2D6 genotype was assessed by automatic sequencing of DNA isolated from peripheral leukocytes, phenotype was assessed using dextromethorphan as a probe substrate. (cs)
Title	CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment (en) CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment (cs)
skos:prefLabel	CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment (en) CYP2D6 phenotype and genotype determination with respect to prediction of therapeutic response in first episode schizophrenia treatment (cs)
skos:notation	RIV/00216224:14110/11:00056990!RIV12-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NS9676)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Juřica, Jan Šulcová, Alexandra Barteček, Richard Zendulka, Ondřej Kašpárek, Tomáš
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	192611
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/11:00056990
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	CYP2D6; genotype; phenotype; schizophrenia (en)
http://linked.open.../riv/klicoveSlovo	schizophrenia genotype phenotype CYP2D6
http://linked.open...ontrolniKodProRIV	[04F2B082ED56]
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of pharmacogenetic and pharmacokinetic factors on the efficacy and safety of the first schizophrenia episodes therapy
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Barteček, Richard Juřica, Jan Kašpárek, Tomáš Pindurová, Eva Šulcová, Alexandra Zendulka, Ondřej
http://localhost/t...ganizacniJednotka	14110

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