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  • To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. Methods HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF. In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman.
  • To determine intraindividual variability in concentrations of homocysteine and related thiols in follicular fluids of particular follicles after ovarian stimulation and assess the differences between follicles with/or without oocytes. Methods HPLC-FD analysis of plasma and follicular fluid cysteine, homocysteine, cysteinylglycine and glutathione in women undergoing IVF. In blood plasma, the homocysteine, cysteine, and cysteinylglycine concentrations decreased significantly during stimulation with rec FSH (p<0.001). We found significant differences in concentrations of cysteine and glutathione between follicles with or without retrieved oocytes. High intraindividual variability in concentrations of thiols was determined. The concentration variability of thiols between single follicles is very high and we recommend mean at least from 3 follicles with/or without oocytes for characterization of each woman. (en)
Title
  • Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid
  • Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid (en)
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  • Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid
  • Intraindividual variability of homocysteine and related thiols concentrations in follicular fluid (en)
skos:notation
  • RIV/00216224:14110/11:00056980!RIV12-MZ0-14110___
http://linked.open...avai/predkladatel
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  • P(NS9661)
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  • 9
http://linked.open...vai/riv/dodaniDat
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  • 205557
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  • RIV/00216224:14110/11:00056980
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  • Homocysteine; Thiols; Follicular fluid; Oocytes (en)
http://linked.open.../riv/klicoveSlovo
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  • DE - Spolková republika Německo
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  • [972184D43212]
http://linked.open...i/riv/nazevZdroje
  • Journal of Assisted Reproduction and Genetics
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  • 28
http://linked.open...iv/tvurceVysledku
  • Crha, Igor
  • Jarkovský, Jiří
  • Králíková, Michaela
  • Matejovičová, Milena
  • Melounová, Jitka
  • Žáková, Jana
  • Tallová, Jaroslava
http://linked.open...ain/vavai/riv/wos
  • 000294808400014
issn
  • 1058-0468
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s10815-011-9606-9
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  • 14110
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