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  • Cellular senescence leads to an irreversible block of cellular division capacity both in cell culture and in vivo. The induction of an irreversible cell cycle arrest is very useful for treatment of cancer. Histone deacetylases (HDACs) are considered as therapeutic targets to treat cancer patients. HDAC inhibitors repress cancer growth and are used in various clinical trials. Here, we analyzed whether sodium butyrate (NaBu), an inhibitor of class I and II HDACs, induces cellular senescence in neuroblastoma and prostate cancer (PCa) including an androgen-dependent as well as an androgenindependent human PCa cell line. We found that the HDAC inhibitors NaBu and valproic acid (VPA) induce cellular senescence in tumor cells. Interestingly, also an inhibitor of SIRT1, a class HDAC III, induces cellular senescence.
  • Cellular senescence leads to an irreversible block of cellular division capacity both in cell culture and in vivo. The induction of an irreversible cell cycle arrest is very useful for treatment of cancer. Histone deacetylases (HDACs) are considered as therapeutic targets to treat cancer patients. HDAC inhibitors repress cancer growth and are used in various clinical trials. Here, we analyzed whether sodium butyrate (NaBu), an inhibitor of class I and II HDACs, induces cellular senescence in neuroblastoma and prostate cancer (PCa) including an androgen-dependent as well as an androgenindependent human PCa cell line. We found that the HDAC inhibitors NaBu and valproic acid (VPA) induce cellular senescence in tumor cells. Interestingly, also an inhibitor of SIRT1, a class HDAC III, induces cellular senescence. (en)
Title
  • Sodium butyrate induces cellular senescence in neuroblastoma and prostate cancer cells
  • Sodium butyrate induces cellular senescence in neuroblastoma and prostate cancer cells (en)
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  • Sodium butyrate induces cellular senescence in neuroblastoma and prostate cancer cells
  • Sodium butyrate induces cellular senescence in neuroblastoma and prostate cancer cells (en)
skos:notation
  • RIV/00216224:14110/11:00055624!RIV12-MSM-14110___
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  • 230278
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  • RIV/00216224:14110/11:00055624
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  • cellular senescence; epigenetic modulators; neuroblastoma; prostate cancer cells (en)
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  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [160CC144D9F2]
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  • Hormone Molecular Biology and Clinical Investigation
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  • 7
http://linked.open...iv/tvurceVysledku
  • Kyrylenko, Sergiy
  • Baniahmad, Aria
  • Hessenkemper, Wiebke
  • Kraft, Florian
  • Lorenz, Viola
  • Rodiger, Julia
issn
  • 1868-1883
number of pages
http://bibframe.org/vocab/doi
  • 10.1515/HMBCI.2011.020
http://localhost/t...ganizacniJednotka
  • 14110
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