About: Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity. Prognosis for children with relapsed medulloblastoma remains poor. Metronomic chemotherapy may offer some benefit to patients treated initially with intensive regimens. However, dosing and duration of such palliative treatment have not been systematically studied. Here we describe a child with medulloblastoma relapsing after initial high-dose chemotherapy and standard radiotherapy. The patient was then treated with metronomic chemotherapy and achieved second complete remission after 21 months of treatment. Three months off therapy he relapsed again and died from progressive disease. This case illustrates the potential benefit of metronomic chemotherapy but also shows the uncertainty of when to stop metronomic chemotherapy while balancing toxicity. (en)
Title	Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. (en)
skos:prefLabel	Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. (en)
skos:notation	RIV/00216224:14110/10:00056962!RIV12-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR9341), P(NS9873), Z(MZ0MOU2005)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štěrba, Jaroslav Valík, Dalibor Dubská, Lenka Pavelka, Zdeněk Bajčiová, Viera Skotáková, Jarmila Ventruba, Jiří Zapletalová, Danica
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	286620
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00056962
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metronomic chemotherapy; relapsed medulloblastoma (en)
http://linked.open.../riv/klicoveSlovo	metronomic chemotherapy relapsed medulloblastoma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EB5D44E39BF4]
http://linked.open...i/riv/nazevZdroje	Pediatric Blood Cancer
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulation of antineoplastic effect of retinoids by LOX/COX inhibitors on the model of solid childhood tumors: in vitro study Miniinvasive endoscopic approach in surgical treatment of childs brain tumors
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Dubská, Lenka Valík, Dalibor Štěrba, Jaroslav Pavelka, Zdeněk André, Nicolas Bajčiová, Viera Skotáková, Jarmila Ventruba, Jiří Zapletalová, Danica
http://linked.open...ain/vavai/riv/wos	000275038900024
http://linked.open...n/vavai/riv/zamer	Functional diagnostics of malignant tumours
issn	1545-5009
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/pbc.22382
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy. Second complete remission of relapsed medulloblastoma induced by metronomic chemotherapy.

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