About: Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children     Goto   Sponge   NotDistinct   Permalink

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  • S100B is a protein biomarker that reflects CNS injury. The aims of the current study were to investigate correlations between the initial level of serum S100B protein and mortality and computerized tomography (CT) findings, as well as to establish whether there is an association between S100B and Glasgow outcome scale (GOS) after six months. This prospective study enrolled 43 patients with traumatic brain injury (TBI), verified by computerized tomography and categorized by Marshall classification. Venous blood samples were taken on admission and every 24 h for a maximum of six consecutive days. The outcome was evaluated six months after TBI using the Glasgow outcome scale (GOS) in all patients. GOS was taken as principal end point for all predictive analyses. We demonstrated statistically significant relationships between groups of patients and increased incidence of some types of injury – intracranial bleeding, subdural haematoma, skull fracture, and oedema.
  • S100B is a protein biomarker that reflects CNS injury. The aims of the current study were to investigate correlations between the initial level of serum S100B protein and mortality and computerized tomography (CT) findings, as well as to establish whether there is an association between S100B and Glasgow outcome scale (GOS) after six months. This prospective study enrolled 43 patients with traumatic brain injury (TBI), verified by computerized tomography and categorized by Marshall classification. Venous blood samples were taken on admission and every 24 h for a maximum of six consecutive days. The outcome was evaluated six months after TBI using the Glasgow outcome scale (GOS) in all patients. GOS was taken as principal end point for all predictive analyses. We demonstrated statistically significant relationships between groups of patients and increased incidence of some types of injury – intracranial bleeding, subdural haematoma, skull fracture, and oedema. (en)
  • S100B is a protein biomarker that reflects CNS injury. The aims of the current study were to investigate correlations between the initial level of serum S100B protein and mortality and computerized tomography (CT) findings, as well as to establish whether there is an association between S100B and Glasgow outcome scale (GOS) after six months. This prospective study enrolled 43 patients with traumatic brain injury (TBI), verified by computerized tomography and categorized by Marshall classification. Venous blood samples were taken on admission and every 24 h for a maximum of six consecutive days. The outcome was evaluated six months after TBI using the Glasgow outcome scale (GOS) in all patients. GOS was taken as principal end point for all predictive analyses. We demonstrated statistically significant relationships between groups of patients and increased incidence of some types of injury – intracranial bleeding, subdural haematoma, skull fracture, and oedema. (cs)
Title
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children (en)
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children (cs)
skos:prefLabel
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children (en)
  • Serum S100B Protein as a Molecular Marker of Severity in Traumatic Brain Injury in Children (cs)
skos:notation
  • RIV/00216224:14110/10:00051304!RIV12-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 287034
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/10:00051304
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • S100protein; severe head injury; outcome; children (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [BECA84F4A431]
http://linked.open...i/riv/nazevZdroje
  • Česká a slovenská neurologie a neurochirurgie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 73/106
http://linked.open...iv/tvurceVysledku
  • Fedora, Michal
  • Žurek, Jiří
  • Marek, Lukáš
  • Bartlová, Ludmila
http://linked.open...ain/vavai/riv/wos
  • 000275593800005
issn
  • 1210-7859
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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