About: Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

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About: Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles. Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles. (en)
Title	Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles (en)
skos:prefLabel	Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles (en)
skos:notation	RIV/00216224:14110/10:00045742!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA102/07/1473), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Nováková, Marie Fialová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	261163
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/10:00045742
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	haloperidol; sigma receptor; IP3 receptor (en)
http://linked.open.../riv/klicoveSlovo	sigma receptor IP3 receptor haloperidol
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[0A72E3E39843]
http://linked.open...i/riv/nazevZdroje	General Physioogy and Biophysics
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Optical Methods for Registration of Heart Electrical Potentials and Calcium Concentration with Laser Stabilization
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Fialová, Kateřina Nováková, Marie Sedláková, Barbora Križanová, Olga Sirová, Marta
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	0231-5882
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

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