About: Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial     Goto   Sponge   NotDistinct   Permalink

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  • The purpose of this study was to test, whether the late phase of remote ischaemic preconditioning (L-RIPC) improves myocardial protection in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether preoperative tramadol modifies myocardial ischaemia-reperfusion injury using the same group of patients in a single-blinded randomized controlled study. One hundred and one adult patients were randomly assigned to either the L-RIPC, control or tramadol group. We found that L-RIPC can reduce injury beyond the myocardial protection provided by cold-crystalloid cardioplegia, and tramadol worsened myocardial injury after CABG. Expressions of iNOS were increased in the control (significantly) and L-RIPC groups and dampened in the tramadol group.
  • The purpose of this study was to test, whether the late phase of remote ischaemic preconditioning (L-RIPC) improves myocardial protection in coronary artery bypass grafting (CABG) with cold-crystalloid cardioplegia and whether preoperative tramadol modifies myocardial ischaemia-reperfusion injury using the same group of patients in a single-blinded randomized controlled study. One hundred and one adult patients were randomly assigned to either the L-RIPC, control or tramadol group. We found that L-RIPC can reduce injury beyond the myocardial protection provided by cold-crystalloid cardioplegia, and tramadol worsened myocardial injury after CABG. Expressions of iNOS were increased in the control (significantly) and L-RIPC groups and dampened in the tramadol group. (en)
Title
  • Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial
  • Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial (en)
skos:prefLabel
  • Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial
  • Myocardial injury is decreased by late remote ischaemic preconditioning and aggravated by tramadol in patients undergoing cardiac surgery: a randomised controlled trial (en)
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  • RIV/00216224:14110/10:00040850!RIV11-MZ0-14110___
http://linked.open...avai/riv/aktivita
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  • P(NR9194)
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  • 6
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  • 273340
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  • RIV/00216224:14110/10:00040850
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  • Myocardial protection; Ischaemic preconditioning; Troponin I; Inducible nitric oxide synthases; Endothelial nitric oxide synthases (en)
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  • CZ - Česká republika
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  • [D23AE3224084]
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  • Interactive CardioVascular and Thoracic Surgery
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  • 11
http://linked.open...iv/tvurceVysledku
  • Freiberger, Tomáš
  • Bedáňová, Helena
  • Wagner, Robert
  • Piler, Pavel
  • Grodecká, Lucie
  • Adamek, Petr
issn
  • 1569-9293
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  • 14110
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