About: Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number of therapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA. No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patients skin symptoms resolved completely and the values of CRP and hemoglobin normalized. Schnitzler syndrome is a rare disorder characterized by chronic urticaria, the presence of monoclonal class IgM immunoglobulin, lymphadenopathy and fevers. We report on a patient who was diagnosed in 1996 and over the next 12 years underwent a number of therapies. Bone pain associated with proven osteolytic and osteosclerotic lesions resolved on regular bisphosphonate treatment with pamidronate and, later, clodronate. The patient had transient benefit from treatments with interferon-alpha and with PUVA. No therapeutic effects were seen with high-dose dexamethasone, 2-chlordeoxyadenosin, cyclosporine, or the combination of bortezomib, thalidomide, and dexamethasone. However, on therapy with anakinra the patients skin symptoms resolved completely and the values of CRP and hemoglobin normalized. (en)
Title	Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens (en)
skos:prefLabel	Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens (en)
skos:notation	RIV/00216224:14110/09:00037270!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06027), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pour, Luděk Prášek, Jiří Büchler, Tomáš Krejčí, Marta Hájek, Roman Adam, Zdeněk Neubauer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	340347
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/09:00037270
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Schnitzler Syndrome; Gammapathy; Urticaria; Anakinra (en)
http://linked.open.../riv/klicoveSlovo	Urticaria Anakinra Gammapathy Schnitzler Syndrome
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[A692975C3BE1]
http://linked.open...i/riv/nazevZdroje	Cancer Therapy
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	University Research Centre - Czech Myeloma Group
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Adam, Zdeněk Hájek, Roman Krejčí, Marta Neubauer, Jiří Prášek, Jiří Pour, Luděk Büchler, Tomáš
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	1543-9135
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens Schnitzler syndrome complete resolution of symptoms on treatment with anakinra after 12 years of unsuccessful therapy with other regimens

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