About: Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment     Goto   Sponge   NotDistinct   Permalink

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  • The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ion channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentration of haloperidol. Hearts from both untreated and chronically to haloperidol exposed animals were investigated. While due to haloperidol administration, the QT prolongation and arrhythmias were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both chronically treated species.
  • The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ion channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentration of haloperidol. Hearts from both untreated and chronically to haloperidol exposed animals were investigated. While due to haloperidol administration, the QT prolongation and arrhythmias were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both chronically treated species. (en)
Title
  • Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
  • Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment (en)
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  • Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
  • Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment (en)
skos:notation
  • RIV/00216224:14110/09:00029671!RIV11-GA0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA102/07/1473), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 303723
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  • RIV/00216224:14110/09:00029671
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • haloperidol; sigma receptor; desensitization; rat; guinea pig; isolated heart; QT interval; arrhythmia (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CA - Kanada
http://linked.open...ontrolniKodProRIV
  • [0BE7C5465C36]
http://linked.open...i/riv/nazevZdroje
  • Canadian Journal of Physiology and Pharmacology
http://linked.open...in/vavai/riv/obor
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http://linked.open...v/svazekPeriodika
  • 87
http://linked.open...iv/tvurceVysledku
  • Jarkovský, Jiří
  • Fialová, Kateřina
  • Nováková, Marie
  • Krizanova, Olga
http://linked.open...ain/vavai/riv/wos
  • 000273419000006
http://linked.open...n/vavai/riv/zamer
issn
  • 1205-7541
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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