About: Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells

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About: Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the number of verified human microRNAs (miRNAs) is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous data suggest altered regulation of microRNA-21 (miR-21) expression in CRC. In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in 60 colorectal tumors and 40 paired adjacent non-tumor tissues and correlated them to selected clinicopathologic features and survival parameters. We used expression of U6 small nuclear RNA (RNU6B) for data normalization and standard ddCt method for relative quantification of miRNA expression. Levels of miR-21 were significantly higher in tumors comparing to normal mucosa (p < 0,0001, Wilcoxon matched-pairs test). Although the number of verified human microRNAs (miRNAs) is still expanding, only few have been functionally described. However, emerging evidences suggest the involvement of altered regulation of miRNA in pathogenesis of cancers and these genes are thought to function as both tumours suppressor and oncogenes. Previous data suggest altered regulation of microRNA-21 (miR-21) expression in CRC. In our study, we examined by Real-Time PCR expression levels of microRNA-21 (miR-21) in 60 colorectal tumors and 40 paired adjacent non-tumor tissues and correlated them to selected clinicopathologic features and survival parameters. We used expression of U6 small nuclear RNA (RNU6B) for data normalization and standard ddCt method for relative quantification of miRNA expression. Levels of miR-21 were significantly higher in tumors comparing to normal mucosa (p < 0,0001, Wilcoxon matched-pairs test). (en)
Title	Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells (en)
skos:prefLabel	Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells (en)
skos:notation	RIV/00216224:14110/08:00028238!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9076)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Slabý, Ondřej Vyzula, Rostislav Svoboda, Marek Slabá, Kateřina
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	374944
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00028238
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colorectal; microRNAs (en)
http://linked.open.../riv/klicoveSlovo	microRNAs colorectal
http://linked.open...ontrolniKodProRIV	[8C5EF3D359AA]
http://linked.open...v/mistoKonaniAkce	Lyon, France
http://linked.open...i/riv/mistoVydani	Oxford, UK
http://linked.open...i/riv/nazevZdroje	European Journal of Cancer Supplements
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene expression profiling-based prediction of treatment response for patient with locally advanced rectal cancer treated by chemotherapy and radiotherapy
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Dubská, Lenka Hrstka, Roman Ovesná, Jaroslava Slabý, Ondřej Svoboda, Marek Vyzula, Rostislav Slabá, Kateřina
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-08-05 (xsd:date)
issn	1359-6349
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells Knockdown of oncogenic microRNA-21 displays cytotoxicity in p53 wild-type colon cancer cells

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