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  • The efficient detection of chromosomal aberrations in childhood acute leukaemias presents a significant component in the diagnostics of this frequent malignant disease. We used comparative genomic hybridization (CGH) and high resolution comparative genomic hybridization (HRCGH) to determine the frequency of chromosomal changes in 33 children with acute leukaemia (AL). The yields of chromosomal abnormalities were compared with the results obtained using conventional cytogenetics (G banding) and fluorescence in situ hybridization (FISH). Conventional cytogenetics revealed chromosomal changes in 17 (52 %) of studied patients. The employment of FISH together with G banding analysis identified chromosomal changes in 27 (82 %) of the AL patients investigated. CGH detected changes in DNA copy numbers in 24 (73 %) patients, 40 losses and 67 gains were found in total. HRCGH disclosed 98 losses and 97 gains in 26 (79 %) patients.
  • The efficient detection of chromosomal aberrations in childhood acute leukaemias presents a significant component in the diagnostics of this frequent malignant disease. We used comparative genomic hybridization (CGH) and high resolution comparative genomic hybridization (HRCGH) to determine the frequency of chromosomal changes in 33 children with acute leukaemia (AL). The yields of chromosomal abnormalities were compared with the results obtained using conventional cytogenetics (G banding) and fluorescence in situ hybridization (FISH). Conventional cytogenetics revealed chromosomal changes in 17 (52 %) of studied patients. The employment of FISH together with G banding analysis identified chromosomal changes in 27 (82 %) of the AL patients investigated. CGH detected changes in DNA copy numbers in 24 (73 %) patients, 40 losses and 67 gains were found in total. HRCGH disclosed 98 losses and 97 gains in 26 (79 %) patients. (en)
Title
  • Efficacy of high - resolution comparative genomic hybridization in detection of chromosomal abnormalities in children with acute leukemia.
  • Efficacy of high - resolution comparative genomic hybridization in detection of chromosomal abnormalities in children with acute leukemia. (en)
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  • Efficacy of high - resolution comparative genomic hybridization in detection of chromosomal abnormalities in children with acute leukemia.
  • Efficacy of high - resolution comparative genomic hybridization in detection of chromosomal abnormalities in children with acute leukemia. (en)
skos:notation
  • RIV/00216224:14110/08:00027620!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita
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  • P(1A8709), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika
  • 1
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  • 365463
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  • RIV/00216224:14110/08:00027620
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  • comparative genomic hybridization (CGH); high resolution comparative genomic hybridization (HRCGH); chromosomal aberrations; acute myeloid leukaemia; acute lymphoid leukaemia (en)
http://linked.open.../riv/klicoveSlovo
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  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [A5D9228A0583]
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  • Neoplasma
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http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Kuglík, Petr
  • Vranová, Vladimíra
  • Štěrba, Jaroslav
  • Filková, Hana
  • Oltová, Alexandra
  • Linková, Vlasta
  • Mendelová, Denisa
  • Mentzlová, Dita
  • Žežulková, Dita
http://linked.open...ain/vavai/riv/wos
  • 000253229000004
http://linked.open...n/vavai/riv/zamer
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  • 0028-2685
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  • 14110
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