About: Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this prospective study, intraepidermal nerve fiber (IENFD) and subepidermal nerve plexus densities (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf in 99 patients with clinical symptoms of painful sensory neuropathy and from 37 age-matched healthy volunteers. The clinical diagnosis was based on history and abnormal thermal thresholds on quantitative sensory testing (QST). In patients with neuropathy, IENFD and SENPD were reduced to about 50% of controls. Elevated warm detection thresholds on QST correlated with IENFD but not with SENPD. Using receiver-operating characteristic curve (ROC) analysis of IENFD values, the diagnostic sensitivity for detecting neuropathy was 0.80 and the specificity 0.82. For SENPD, sensitivity was 0.81 and specificity 0.88. Analyzing both IENFD and SENPD together with ROC analysis, the diagnostic sensitivity was further improved to 0.92. In this prospective study, intraepidermal nerve fiber (IENFD) and subepidermal nerve plexus densities (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf in 99 patients with clinical symptoms of painful sensory neuropathy and from 37 age-matched healthy volunteers. The clinical diagnosis was based on history and abnormal thermal thresholds on quantitative sensory testing (QST). In patients with neuropathy, IENFD and SENPD were reduced to about 50% of controls. Elevated warm detection thresholds on QST correlated with IENFD but not with SENPD. Using receiver-operating characteristic curve (ROC) analysis of IENFD values, the diagnostic sensitivity for detecting neuropathy was 0.80 and the specificity 0.82. For SENPD, sensitivity was 0.81 and specificity 0.88. Analyzing both IENFD and SENPD together with ROC analysis, the diagnostic sensitivity was further improved to 0.92. (en)
Title	Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies (en)
skos:prefLabel	Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies (en)
skos:notation	RIV/00216224:14110/08:00025711!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR7993), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bednařík, Josef Dušek, Ladislav Moravcová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	363228
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00025711
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	skin biopsy; epidermal nerve fiber density; painful neuropathy; quantitative sensory testing; skin biopsy; subepidermal nerve fiber density (en)
http://linked.open.../riv/klicoveSlovo	epidermal nerve fiber density painful neuropathy subepidermal nerve fiber density skin biopsy quantitative sensory testing
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BE700C8C6D7C]
http://linked.open...i/riv/nazevZdroje	Muscle & Nerve
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Prognostic factors of premyelopathic spondylotic cervical cord compression : 5-year prospective observational cohort study
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	37
http://linked.open...iv/tvurceVysledku	Bednařík, Josef Dušek, Ladislav Vlčková, Eva Sommer, Claudia Toyka, Klaus
http://linked.open...ain/vavai/riv/wos	000252114200008
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	0148-639X
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies

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