About: TSPY gene copy number as a potential new risk factor for male infertility

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The human TSPY (testis-specific protein, Y-linked) gene family (30-60 copies) is situated in the MSY (male-specific) region of the Y chromosome. Testis-specific expression indicates that the gene plays a role in spermatogenesis. Refined quantitative fluorescence PCR (polymerase chain reaction) was applied to evaluate the relative number of TSPY copies compared with AMELY/X (amelogenin gene, Y-linked) genes in 84 stratified infertile men and in 40 controls. A significantly higher number of TSPY copies was found in infertile men compared with the controls (P = 0.002). The diagnostic discrimination potential of the relative number of TSPY copies was evaluated by receiver operating characteristic curve analysis. TSPY/AMELY was unambiguously found to be powerful in the diagnostic separation of both the control samples and the infertile men, reaching a good level of specificity (0.642) and sensitivity (0.732) at a cut-off point of 0.46. The human TSPY (testis-specific protein, Y-linked) gene family (30-60 copies) is situated in the MSY (male-specific) region of the Y chromosome. Testis-specific expression indicates that the gene plays a role in spermatogenesis. Refined quantitative fluorescence PCR (polymerase chain reaction) was applied to evaluate the relative number of TSPY copies compared with AMELY/X (amelogenin gene, Y-linked) genes in 84 stratified infertile men and in 40 controls. A significantly higher number of TSPY copies was found in infertile men compared with the controls (P = 0.002). The diagnostic discrimination potential of the relative number of TSPY copies was evaluated by receiver operating characteristic curve analysis. TSPY/AMELY was unambiguously found to be powerful in the diagnostic separation of both the control samples and the infertile men, reaching a good level of specificity (0.642) and sensitivity (0.732) at a cut-off point of 0.46. (en)
Title	TSPY gene copy number as a potential new risk factor for male infertility TSPY gene copy number as a potential new risk factor for male infertility (en)
skos:prefLabel	TSPY gene copy number as a potential new risk factor for male infertility TSPY gene copy number as a potential new risk factor for male infertility (en)
skos:notation	RIV/00216224:14110/07:00040020!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(NR7821), P(NR8442), V
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dušek, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	455941
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00040020
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	capillary electrophoresis; male infertility; multicopy gene; quantitative fluorescence PCR; TSPY gene; Y chromosome (en)
http://linked.open.../riv/klicoveSlovo	capillary electrophoresis TSPY gene Y chromosome male infertility multicopy gene quantitative fluorescence PCR
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F14298F50392]
http://linked.open...i/riv/nazevZdroje	Reproductive Biomedicine Online
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	The influence of TSPY gene sequence, repetition and expression variability on biological function in normal and pathological cells. Standardization and individualization of germ-cell tumour treatment (preparing centralization of all care to two centers in CR)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Dušek, Ladislav Šantavý, J. Dostal, J. Brezinova, J. Vrtel, R. Sobek, A. Vodicka, R. Horinova, V. Krizova, K. Oborna, I. Singh, A. R. Svacinova, V.
issn	1472-6491
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	TSPY gene copy number as a potential new risk factor for male infertility TSPY gene copy number as a potential new risk factor for male infertility TSPY gene copy number as a potential new risk factor for male infertility

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