About: Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma.

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About: Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated the presence of individual melanoma-specific T cell clones in patients with metastatic melanoma. Ten patients were examined for the presence of melanoma-reactive T cells using dendritic cells loaded with autologous tumor cells. Their specificity was tested using nonradioactive cytotoxicity test. Individual immumodominant T cell clones were identified by the clonotypic assay that combines in vitro cell culture, immunomagnetic sorting of activated IFN-gamma(+) T cells, TCR beta locus-anchored RT-PCR, and clonotypic quantitative PCR. All patients had detectable melanoma-reactive T cells in vitro. Expanded melanoma-reactive T cells demonstrated specific cytotoxic effect against autologous tumor cells in vitro. Three patients experienced objective responses, and their clinical responses were closely associated with the in vivo expansion and long-term persistence of individual CD8(+) T cell clones with frequencies of 10(-6) to 10(-3) of all circulating CD8+ T cells. We investigated the presence of individual melanoma-specific T cell clones in patients with metastatic melanoma. Ten patients were examined for the presence of melanoma-reactive T cells using dendritic cells loaded with autologous tumor cells. Their specificity was tested using nonradioactive cytotoxicity test. Individual immumodominant T cell clones were identified by the clonotypic assay that combines in vitro cell culture, immunomagnetic sorting of activated IFN-gamma(+) T cells, TCR beta locus-anchored RT-PCR, and clonotypic quantitative PCR. All patients had detectable melanoma-reactive T cells in vitro. Expanded melanoma-reactive T cells demonstrated specific cytotoxic effect against autologous tumor cells in vitro. Three patients experienced objective responses, and their clinical responses were closely associated with the in vivo expansion and long-term persistence of individual CD8(+) T cell clones with frequencies of 10(-6) to 10(-3) of all circulating CD8+ T cells. (en)
Title	Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. (en)
skos:prefLabel	Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. (en)
skos:notation	RIV/00216224:14110/07:00033038!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Žaloudík, Jan Fait, Vuk Hájek, Roman Michálek, Jaroslav Kocák, Ivo
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	416508
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00033038
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metastatic melanoma; T cell (en)
http://linked.open.../riv/klicoveSlovo	T cell metastatic melanoma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1D13D141D9D5]
http://linked.open...i/riv/nazevZdroje	Journal of immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	2007
http://linked.open...iv/tvurceVysledku	Hájek, Roman Michálek, Jaroslav Kocák, Ivo Žaloudík, Jan Fait, Vuk
http://linked.open...ain/vavai/riv/wos	000246896300018
issn	0022-1767
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma.

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