About: Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptors mRNA levels. Signalling cascade of sigma receptors is dependent on IP3 receptors, since silencing of both, type 1 and 2 IP3 receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes. The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptors mRNA levels. Signalling cascade of sigma receptors is dependent on IP3 receptors, since silencing of both, type 1 and 2 IP3 receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes. (en)
Title	Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions (en)
skos:prefLabel	Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions (en)
skos:notation	RIV/00216224:14110/07:00024575!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA305/04/1385)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lacinová, Ľubica Nováková, Marie Vašků, Anna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	434790
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00024575
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Sigma receptors; IP3 receptors; Stress; Gene expression (en)
http://linked.open.../riv/klicoveSlovo	Stress IP3 receptors Gene expression Sigma receptors
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[09A5B9D41342]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	26
http://linked.open...iv/tvurceVysledku	Vašků, Anna Nováková, Marie Lacinová, Ľubica Križanová, Olga Kaplan, Peter Kvetňanský, Richard Kopáček, Juraj Bruderová, Viera Jurkovičová, Dana Sulová, Zdena
http://linked.open...ain/vavai/riv/wos	000249388600007
issn	0231-5882
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions

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