About: Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus

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About: Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus. Glutathione S-transferase (GST) enzymes play an important role in cellular protection against oxidative stress and toxic foreign chemicals. So, we investigated the hypothesis that polymorphisms in genes for these detoxifying enzymes could influence susceptibility to RE and Barrett s esophagus. Methods: GSTM1, GSTT1 and GSTP1 loci were analyzed by PCR-based methods in 64 patients with RE (and additional group of 22 subjects with Barrett s esophagus as 4th grade of esophagitis) and 173 unrelated controls.Results: There were no significant differences in the distributions of GSTM1 and GSTT1 genotypes between controls and patients with RE or Barrett s esophagus. Similarly, frequencies of GSTP1 alleles were non-significantly different between control and reflux esophagitis groups. Conclusions: GSTP1 gene might be one of the risk factors associated with susceptibility to reflux esophagitis, especially to Barrett s esophagus. (en)
Title	Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus (en)
skos:prefLabel	Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus (en)
skos:notation	RIV/00216224:14110/07:00023553!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(2B06060)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Dolina, J. Kala, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	442209
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00023553
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	GERD; GSTs; glutathione S-transferase; polymorphism; reflux esophagitis; gene (en)
http://linked.open.../riv/klicoveSlovo	reflux esophagitis gene polymorphism glutathione S-transferase GERD GSTs
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[34450D8F1A64]
http://linked.open...i/riv/nazevZdroje	Journal of Hum Genetics
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Increasing the efficacy of the diagnostics and treatment of gastro-esophageal reflux disease.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Kala, Zdeněk Dolina, Jiří Marek, F. Izakovičová-Holá, L.
issn	1434-5161
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus Polymorhism of glutathione S-transferase M1, T1 and P1 in patients with reflux esophagitis and Barrett´s esophagus

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