About: Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities.

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About: Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Quaternary benzo[c]phenanthridine alkaloids are a relatively small group of isoquinoline alkaloids with attractive biological activities. They are produced by a number of plant species of the Papaveraceae, Fumariaceae and Rutaceae families. Differential cytotoxicity of minor naturally occurring derivatives sanguirubine, chelirubine and macarpine and better known benzophenanthridines sanguinarine and chelerythrine in cancer and normal cells was assessed in vitro by MTT assay using a panel consisting of either transformed cell lines (HeLa; A431; HL60) or primary fibroblasts of human origin. IC50 values were determined 72 h after addition of the alkaloids. A wide range (0.01-1.44 mg/ml) of IC50 was observed and the highest toxicity was determined for macarpine. Human promyelocytic leukemia line HL60 has been documented the most sensitive to alkaloid treatment followed by human skin fibroblasts, while human cervix adenocarcinoma HeLa cells and epidermal carcinoma cells A431 appeared more resistant. Quaternary benzo[c]phenanthridine alkaloids are a relatively small group of isoquinoline alkaloids with attractive biological activities. They are produced by a number of plant species of the Papaveraceae, Fumariaceae and Rutaceae families. Differential cytotoxicity of minor naturally occurring derivatives sanguirubine, chelirubine and macarpine and better known benzophenanthridines sanguinarine and chelerythrine in cancer and normal cells was assessed in vitro by MTT assay using a panel consisting of either transformed cell lines (HeLa; A431; HL60) or primary fibroblasts of human origin. IC50 values were determined 72 h after addition of the alkaloids. A wide range (0.01-1.44 mg/ml) of IC50 was observed and the highest toxicity was determined for macarpine. Human promyelocytic leukemia line HL60 has been documented the most sensitive to alkaloid treatment followed by human skin fibroblasts, while human cervix adenocarcinoma HeLa cells and epidermal carcinoma cells A431 appeared more resistant. (en)
Title	Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. (en)
skos:prefLabel	Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. (en)
skos:notation	RIV/00216224:14110/07:00020083!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/04/0017), P(GD301/03/H005), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vlková, Marcela Táborská, Eva Slaninová, Iva Slunská, Zdenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	449063
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00020083
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; annexin V; benzo[c]phenanthridine alkaloids; cytotoxicity; chelerythrine; chelirubine; macarpine; MTT assay; sanguinarine; sanguirubine (en)
http://linked.open.../riv/klicoveSlovo	cytotoxicity MTT assay benzo[c]phenanthridine alkaloids macarpine chelirubine apoptosis annexin V chelerythrine sanguinarine sanguirubine
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[04435F678F88]
http://linked.open...i/riv/nazevZdroje	Pharmaceutical Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and cell biology in biomedicine Plant sources of benzophenanthridine alkaloids and effects of these alkaloids on normal and cancer cells
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Slaninová, Iva Táborská, Eva Vlková, Marcela Šinkora, Jiří Slunská, Zdenka
http://linked.open...ain/vavai/riv/wos	000245677200009
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1388-0209
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities. Screening of minor benzo(c)phenanthridine alkaloids for antiproliferative and apoptotic activities.

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