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  • Background: The risk of POF onset depends mainly on womens age and foliculogenesis status in ovary, chemotherapy (CT) regimen used and cumulative dose of single cytotoxic agents. Aims: Aim of this prospective case-control study is evaluation of gonadoliberine analogues (GnRHa) administration to patients with Hodgkins lymphoma (HL) during chemotherapy and prevention of ovarian damage depending upon CT dose and regimen. Methods: Study group consists of 72 patients in fertile age with HL by curative CT together with GnRHa administration according standardized protocol. Group A received ABVD, group B baseline BEACOPP and ABVD in combination, group C dose escalated BEACOPP regimen. Results: In study group with GnRHa administration during CT there was statistical significantly less cases with POF (38.2 %) in 6 month after end of CT than in control group (73.4 %). After 12 month POF was detected in 48.8 % of cases versus 69.3 % in control group.
  • Background: The risk of POF onset depends mainly on womens age and foliculogenesis status in ovary, chemotherapy (CT) regimen used and cumulative dose of single cytotoxic agents. Aims: Aim of this prospective case-control study is evaluation of gonadoliberine analogues (GnRHa) administration to patients with Hodgkins lymphoma (HL) during chemotherapy and prevention of ovarian damage depending upon CT dose and regimen. Methods: Study group consists of 72 patients in fertile age with HL by curative CT together with GnRHa administration according standardized protocol. Group A received ABVD, group B baseline BEACOPP and ABVD in combination, group C dose escalated BEACOPP regimen. Results: In study group with GnRHa administration during CT there was statistical significantly less cases with POF (38.2 %) in 6 month after end of CT than in control group (73.4 %). After 12 month POF was detected in 48.8 % of cases versus 69.3 % in control group. (en)
Title
  • Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration
  • Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration (en)
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  • Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration
  • Prevention of ovarian damage during chemotherapy by gonadoliberine analogues administration (en)
skos:notation
  • RIV/00216224:14110/07:00019138!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita
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  • P(NR8469)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 444033
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  • RIV/00216224:14110/07:00019138
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  • Hodgkins lymphoma; gonadoliberine analogues; premature ovarian failure (en)
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  • [227B2728BEE5]
http://linked.open...in/vavai/riv/obor
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  • Crha, Igor
  • Huser, Martin
  • Ventruba, Pavel
  • Král, Zdeněk
  • Vorlíček, Jiří
  • Šmardová, Lenka
http://localhost/t...ganizacniJednotka
  • 14110
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