About: THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL)

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About: THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Apoptosis plays an important role in normal and malignant lymphopoiesis. Therefore signaling pathways participating in this process are intensively investigated to find their crucial molecules suitable for development and application of new antineoplastic agents. Aims: Based on results of our previous studies and literature search, we selected 9 molecules which play an important role in survival of malignant cells to validate their impact for prediction of outcome in DLBCL. Methods and materials: We studied 46 patients with primary DLBCL.The group consisted of 29 men and 27 women with a median age of 59 years (range, 24-79). Advanced stage (III/IV) was observed in 24 cases (52%) and the distribution according to the IPI was as follows: low risk, 20 cases (44%); low/intermediate risk, 12 (26%); high/intermediate risk 9 (19%); and high risk, 5 (11%). Background: Apoptosis plays an important role in normal and malignant lymphopoiesis. Therefore signaling pathways participating in this process are intensively investigated to find their crucial molecules suitable for development and application of new antineoplastic agents. Aims: Based on results of our previous studies and literature search, we selected 9 molecules which play an important role in survival of malignant cells to validate their impact for prediction of outcome in DLBCL. Methods and materials: We studied 46 patients with primary DLBCL.The group consisted of 29 men and 27 women with a median age of 59 years (range, 24-79). Advanced stage (III/IV) was observed in 24 cases (52%) and the distribution according to the IPI was as follows: low risk, 20 cases (44%); low/intermediate risk, 12 (26%); high/intermediate risk 9 (19%); and high risk, 5 (11%). (en)
Title	THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) (en)
skos:prefLabel	THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) (en)
skos:notation	RIV/00216224:14110/07:00019098!RIV10-MZ0-14110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8335)
http://linked.open...iv/cisloPeriodika	S1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vášová, Ingrid Rejthar, Aleš Svoboda, Marek Klabusay, Martin Fabian, Pavel Nenutil, Rudolf
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	425596
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/07:00019098
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Akt; DLBCL; Prognostic factor; Survivin (en)
http://linked.open.../riv/klicoveSlovo	Akt DLBCL Prognostic factor Survivin
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[D20054C9839B]
http://linked.open...i/riv/nazevZdroje	Haematologica/the hematology journal
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Prediction of chemosensitivity / chemoresistance to the target therapy of breast carcinoma with amplification of the Her-2 gene, based on the analysis of Akt signal pathway and serial quantitative testing for serum HER-2/neu extracellular domain
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	2007
http://linked.open...iv/tvurceVysledku	Radová, Lenka Vášová, Ingrid Svoboda, Marek Berkovcová, Jitka Fabian, Pavel Klabusay, Martin Nenutil, Rudolf Rejthar, Aleš
issn	0390-6078
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) THE IMPACT OF SELECTED CELL SURVIVAL REGULATORS (OF AKT-2, BCL-2, CD29, PKC-DELTA AND SURVIVIN) ON PREDICTION OF CLINICAL OUTCOME IN DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL)

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