About: Functional polymer hydrogels for embryonic stem cell support

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	One of the most exciting challenges in development of transplantation therapies is to repair the damaged part of the organ or tissue by transplantation of undifferentiated embryonic stem (ES) cells or their differentiated derivatives within three-dimensional polymer scaffold. To address this issue, new cationic hydrogel slabs were synthesized by bulk radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) with ethylene dimethacrylate (EDMA) or 1-vinyl-2-pyrrolidone (VP) with N,N'-divinylethyleneurea (DVEU) or EDMA in the presence of saccharose or NaCl as a porogen. Biocompatibility was studied with the use of feeder-independent mouse ES cell line D3. When cultured for a limited period of time, ES cells retained their undifferentiated state independently of properties of the hydrogel slabs. Notably, prolonged culture in superporous hydrogel slabs initiated ES cell differentiation. One of the most exciting challenges in development of transplantation therapies is to repair the damaged part of the organ or tissue by transplantation of undifferentiated embryonic stem (ES) cells or their differentiated derivatives within three-dimensional polymer scaffold. To address this issue, new cationic hydrogel slabs were synthesized by bulk radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) with ethylene dimethacrylate (EDMA) or 1-vinyl-2-pyrrolidone (VP) with N,N'-divinylethyleneurea (DVEU) or EDMA in the presence of saccharose or NaCl as a porogen. Biocompatibility was studied with the use of feeder-independent mouse ES cell line D3. When cultured for a limited period of time, ES cells retained their undifferentiated state independently of properties of the hydrogel slabs. Notably, prolonged culture in superporous hydrogel slabs initiated ES cell differentiation. (en)
Title	Functional polymer hydrogels for embryonic stem cell support Functional polymer hydrogels for embryonic stem cell support (en)
skos:prefLabel	Functional polymer hydrogels for embryonic stem cell support Functional polymer hydrogels for embryonic stem cell support (en)
skos:notation	RIV/00216224:14110/06:00028366!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0538), P(GA301/05/0463), Z(AV0Z40500505), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pacherník, Jiří Dvořák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	476466
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00028366
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hydrogel; cationic; embryonic stem cells; 2-hydroxyethyl methacrylate; 1-vinyl-2-pyrrolidone (en)
http://linked.open.../riv/klicoveSlovo	embryonic stem cells cationic 1-vinyl-2-pyrrolidone hydrogel 2-hydroxyethyl methacrylate
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9141EA687BAE]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedical Materials Research
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Cell Therapy and Tissue Repair Cell cycle regulation in human embryonic stem cells - study toward establishing identifiable characteristics of high quality cells
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Dvořák, Petr Pacherník, Jiří Šlouf, M. Kroupová, J. Horák, D.
http://linked.open...ain/vavai/riv/wos	000234834700010
http://linked.open...n/vavai/riv/zamer	Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	1549-3296
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Functional polymer hydrogels for embryonic stem cell support Functional polymer hydrogels for embryonic stem cell support

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