About: Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities     Goto   Sponge   NotDistinct   Permalink

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  • Evaluation of intra-epidermal nerve fiber density (IENFD) has become a standard tool in the diagnosis of painful sensory neuropathy. However, changes in the density of the subepidermal nerve plexus (SENFD) have never been systematically studied in neuropathy patients. Intra- and subepidermal nerve fiber densities were examined using PGP 9.5-immunostaining of skin-punch biopsy samples from the distal calf in 99 consecutively-recruited patients with clinical symptoms of a painful sensory neuropathy and with abnormal thermal thresholds on quantitative sensory testing (QST), and in 37 age-matched healthy volunteers. Comparison of the groups demonstrated a clear reduction in both IENFD and SENFD in the neuropathy group compared to the healthy controls (p<0.001). The diagnostic validity of IENFD and SENFD was assessed in receiver-operating characteristic curve (ROC) analysis. Using a cut-off value of 8.8 fibers/mm, the sensitivity of IENFD examination was 0.80 and the specificity 0.82.
  • Evaluation of intra-epidermal nerve fiber density (IENFD) has become a standard tool in the diagnosis of painful sensory neuropathy. However, changes in the density of the subepidermal nerve plexus (SENFD) have never been systematically studied in neuropathy patients. Intra- and subepidermal nerve fiber densities were examined using PGP 9.5-immunostaining of skin-punch biopsy samples from the distal calf in 99 consecutively-recruited patients with clinical symptoms of a painful sensory neuropathy and with abnormal thermal thresholds on quantitative sensory testing (QST), and in 37 age-matched healthy volunteers. Comparison of the groups demonstrated a clear reduction in both IENFD and SENFD in the neuropathy group compared to the healthy controls (p<0.001). The diagnostic validity of IENFD and SENFD was assessed in receiver-operating characteristic curve (ROC) analysis. Using a cut-off value of 8.8 fibers/mm, the sensitivity of IENFD examination was 0.80 and the specificity 0.82. (en)
Title
  • Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities
  • Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities (en)
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  • Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities
  • Diagnostic validity of skin biopsy in painful sensory neuropathy utilising intra- and subepidermal nerve fiber densities (en)
skos:notation
  • RIV/00216224:14110/06:00017808!RIV11-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM0021622404)
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  • 471381
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  • RIV/00216224:14110/06:00017808
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  • skin biopsy; painful neuropathy; small-fibers (en)
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  • [7F0C1CB515DD]
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  • Bednařík, Josef
  • Dušek, Ladislav
  • Vlčková, Eva
  • Sommer, C.
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14110
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