About: Increased plasma levels of sRAGE in patients with diabetic nephropathy

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About: Increased plasma levels of sRAGE in patients with diabetic nephropathy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background and Aims: Advanced Glycation End products (AGEs) accumulate in diabetic patients in a greater rate than in age-matched non-diabetic subjects and exert various adverse effects via the Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a 50kDa naturally occurring C-terminally truncated form of RAGE that functions as an inhibitor of AGE-mediated signalling events. Decreased levels of supposedly protective sRAGE were ascertained in patients with macrovascular disease and hypertension. Data about the role of sRAGE in diabetic nephropathy are so far lacking. The aim of the study was to analyse the relationship between sRAGE and renal functions in subjects with diabetic nephropathy and, hereby, implicit protective capacity against AGE-mediated toxicity. Material and Methods: Study was designed as a cross-sectional analysis of a cohort of 255 diabetic patients with variable extent of diabetic nephropathy. Total number of subjects consisted if 36 diabetics with T1DM, 219 with T2DM (approx. Background and Aims: Advanced Glycation End products (AGEs) accumulate in diabetic patients in a greater rate than in age-matched non-diabetic subjects and exert various adverse effects via the Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a 50kDa naturally occurring C-terminally truncated form of RAGE that functions as an inhibitor of AGE-mediated signalling events. Decreased levels of supposedly protective sRAGE were ascertained in patients with macrovascular disease and hypertension. Data about the role of sRAGE in diabetic nephropathy are so far lacking. The aim of the study was to analyse the relationship between sRAGE and renal functions in subjects with diabetic nephropathy and, hereby, implicit protective capacity against AGE-mediated toxicity. Material and Methods: Study was designed as a cross-sectional analysis of a cohort of 255 diabetic patients with variable extent of diabetic nephropathy. Total number of subjects consisted if 36 diabetics with T1DM, 219 with T2DM (approx. (en)
Title	Increased plasma levels of sRAGE in patients with diabetic nephropathy Increased plasma levels of sRAGE in patients with diabetic nephropathy (en)
skos:prefLabel	Increased plasma levels of sRAGE in patients with diabetic nephropathy Increased plasma levels of sRAGE in patients with diabetic nephropathy (en)
skos:notation	RIV/00216224:14110/06:00015385!RIV11-AV0-14110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(KJB501620601), S
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Hertlová, Miluše Zima, Tomáš Kaňková, Kateřina Krusová, Darja
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	479189
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/06:00015385
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetes mellitus; diabetic nephropathy; RAGE; AGEs; susceptibility (en)
http://linked.open.../riv/klicoveSlovo	AGEs diabetes mellitus - insulin resistance - ethiopathogenesis - diagnostic criteria - late complications - advanced age - treatment susceptibility RAGE diabetic nephropathy
http://linked.open...ontrolniKodProRIV	[D6FEF5D7C4F2]
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Hertlová, Miluše Kalousová, Marta Zima, Tomáš Kaňková, Kateřina Krusová, Darja
http://localhost/t...ganizacniJednotka	14110

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