About: Role of GABAA alpha 5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist     Goto   Sponge   NotDistinct   Permalink

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  • GABAA receptors containing ŚÁ5 subunits have been suggested to mediate the rewarding effects of ethanol. We tested this hypothesis in mice with deletion of alpha5 subunits. Alpha5 knockout mice did not differ from wildtypes in operant responding for 10% ethanol/10% sucrose, but responded less for 10% sucrose. The benzodiazepine (BZ) site inverse agonist, Ro 15-4513, has higher affinity for GABAA receptors containing 5 subunits and dose-dependently (0,27 mg/kg, i.p.) reduced lever pressing for ethanol/sucrose in wildtype mice, but had less effect in knockout mice; lever pressing for sucrose was unaffected. These data suggest that alpha5 subunits are not essential for ethanol reward, but the reduction of operant responding for ethanol by Ro 15-4513 is mediated by alpha5-containing GABAA receptors.
  • GABAA receptors containing ŚÁ5 subunits have been suggested to mediate the rewarding effects of ethanol. We tested this hypothesis in mice with deletion of alpha5 subunits. Alpha5 knockout mice did not differ from wildtypes in operant responding for 10% ethanol/10% sucrose, but responded less for 10% sucrose. The benzodiazepine (BZ) site inverse agonist, Ro 15-4513, has higher affinity for GABAA receptors containing 5 subunits and dose-dependently (0,27 mg/kg, i.p.) reduced lever pressing for ethanol/sucrose in wildtype mice, but had less effect in knockout mice; lever pressing for sucrose was unaffected. These data suggest that alpha5 subunits are not essential for ethanol reward, but the reduction of operant responding for ethanol by Ro 15-4513 is mediated by alpha5-containing GABAA receptors. (en)
Title
  • Role of GABAA alpha 5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist
  • Role of GABAA alpha 5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist (en)
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  • Role of GABAA alpha 5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist
  • Role of GABAA alpha 5-containing receptors in ethanol reward: The effects of targeted gene deletion, and a selective inverse agonist (en)
skos:notation
  • RIV/00216224:14110/05:00021428!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
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  • Z(MSM 141100001)
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  • 1-3
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  • 541405
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  • RIV/00216224:14110/05:00021428
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  • ethanol; reward; GABA; self-administration; Ro 15-4513 (en)
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  • NL - Nizozemsko
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  • [ABE4487BABD6]
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  • European Journal of Pharmacology
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  • 526
http://linked.open...iv/tvurceVysledku
  • Pistovčáková, Jana
  • Atack R., John
  • Dawson R., Gerard
  • Stephens N., David
  • Worthing, Lynn
http://linked.open...ain/vavai/riv/wos
  • 000233958700022
http://linked.open...n/vavai/riv/zamer
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  • 0014-2999
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  • 14110
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