About: Relevance of immunological variables in neuroborreliosis and multiple sclerosis     Goto   Sponge   NotDistinct   Permalink

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  • The aims were to investigate the frequency of intrathecal synthesis of specific antibodies against measles (M), rubella(R),and varicella zoster (Z)viruses(MRZ reaction) as a diagnostic marker between multiple sclerosis (MS) and neuroborreliosis (NB)groups and to postulate the most typical cerebrospinal fluid (CSF) variables profile of these entities. Three cohorts of patients were investigated :MS (n=42),NB (n=27) and other neurological diseases (OND) (n=15).Measles, rubella varicella zoster and borrelia specific IgG antibodies were measured by ELISA , Qalb as a marker of blood -CSF barrier function and specific antibody indices (AI) were calculated according to relevant formulae. IgG oligoclonal bands (OB) were detected by isoelectric focusing and immunoenzymatic staining. Results : Eighty- eight percent of MS patients had positive MRZ reaction and 26.2% had positive anti -borrelia AI.
  • The aims were to investigate the frequency of intrathecal synthesis of specific antibodies against measles (M), rubella(R),and varicella zoster (Z)viruses(MRZ reaction) as a diagnostic marker between multiple sclerosis (MS) and neuroborreliosis (NB)groups and to postulate the most typical cerebrospinal fluid (CSF) variables profile of these entities. Three cohorts of patients were investigated :MS (n=42),NB (n=27) and other neurological diseases (OND) (n=15).Measles, rubella varicella zoster and borrelia specific IgG antibodies were measured by ELISA , Qalb as a marker of blood -CSF barrier function and specific antibody indices (AI) were calculated according to relevant formulae. IgG oligoclonal bands (OB) were detected by isoelectric focusing and immunoenzymatic staining. Results : Eighty- eight percent of MS patients had positive MRZ reaction and 26.2% had positive anti -borrelia AI. (en)
Title
  • Relevance of immunological variables in neuroborreliosis and multiple sclerosis
  • Relevance of immunological variables in neuroborreliosis and multiple sclerosis (en)
skos:prefLabel
  • Relevance of immunological variables in neuroborreliosis and multiple sclerosis
  • Relevance of immunological variables in neuroborreliosis and multiple sclerosis (en)
skos:notation
  • RIV/00216224:14110/05:00014962!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 540684
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00014962
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • MRZ reaction; multiple sclerosis; neuroborreliosis; immunological variables (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [50FCA712A6EB]
http://linked.open...i/riv/nazevZdroje
  • Acta Neurologica Scandinavica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 112/2005
http://linked.open...iv/tvurceVysledku
  • Štourač, Pavel
  • Adam, Pavel
  • Bednářová, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 0001-6314
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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