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Description
| - Kanabidiol je bioprekurzor tetrahydrokanabinolu (THC) bez psychotomimetických účinků. V literatuře se uvádí jeho potenciální antikonvulsivní, antipsychotické, antidepresivní, antiemetické a protizánětlivé působení. V naší studii jsme s použitím modelu opakovaných párových interakcí dospělých myších samců hodnotili potenciálně antidepresivní behaviorální účinky kanabidiolu. Naše výsledky v souladu s humánními studiemi naznačují anxiolytické, případně antidepresivní působení kanabidiolu. (cs)
- Cannabidiol, a nonpsychotropic cannabis constituent, with potential anticonvulsive, antianxiety, antipsychotic, antiemetic, and anti-inflammatory properties (Mechoulam et al., 2002) was tested for its behavioural effects in the mouse model of social defeat using a naturally occurring intra-species social conflict situation. The present study investigated effects of cannabidiol on locomotor behavioural changes in the open field in non-aggressive group-housed male mice which served several times as opponents to aggressive singly-housed mice. The results suggest a potential anxiolytic effect of cannabidiol in mice defeated by an aggressive conspecific partner.
- Cannabidiol, a nonpsychotropic cannabis constituent, with potential anticonvulsive, antianxiety, antipsychotic, antiemetic, and anti-inflammatory properties (Mechoulam et al., 2002) was tested for its behavioural effects in the mouse model of social defeat using a naturally occurring intra-species social conflict situation. The present study investigated effects of cannabidiol on locomotor behavioural changes in the open field in non-aggressive group-housed male mice which served several times as opponents to aggressive singly-housed mice. The results suggest a potential anxiolytic effect of cannabidiol in mice defeated by an aggressive conspecific partner. (en)
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Title
| - Effect of cannabidiol on behavioural changes elicited by social defeat in mice
- Účinky kanabidiolu na změny chování vyvolané sociální porážkou u myší (cs)
- Effect of cannabidiol on behavioural changes elicited by social defeat in mice (en)
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skos:prefLabel
| - Effect of cannabidiol on behavioural changes elicited by social defeat in mice
- Účinky kanabidiolu na změny chování vyvolané sociální porážkou u myší (cs)
- Effect of cannabidiol on behavioural changes elicited by social defeat in mice (en)
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skos:notation
| - RIV/00216224:14110/05:00014434!RIV09-MSM-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/05:00014434
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cannabidiol; social defeat; mice; antidepressant; animal model (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - European Neuropsychopharmacology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Šulcová, Alexandra
- Pistovčáková, Jana
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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