About: IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN     Goto   Sponge   NotDistinct   Permalink

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  • Immunoreactivity for pCREB was localized surprisingly in the nucleoli of the DRG neurons of both naive and operated rats. In comparison to DRG neurons from naive rats, significant increased immunostaining for pCREB was found in the neurons of both ipsilateral and contralateral DRG following various types of nerve injuries. The present results demonstrated that increased phosphorylation of CREB induced by nerve injury may be involved in the development neuropathic pain. Similar bilateral exhibition of increased pCREB immunostaining suggested a retrograde neuroinflammation signalling of the neuropathic pain development.
  • Immunoreactivity for pCREB was localized surprisingly in the nucleoli of the DRG neurons of both naive and operated rats. In comparison to DRG neurons from naive rats, significant increased immunostaining for pCREB was found in the neurons of both ipsilateral and contralateral DRG following various types of nerve injuries. The present results demonstrated that increased phosphorylation of CREB induced by nerve injury may be involved in the development neuropathic pain. Similar bilateral exhibition of increased pCREB immunostaining suggested a retrograde neuroinflammation signalling of the neuropathic pain development. (en)
Title
  • IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN
  • IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN (en)
skos:prefLabel
  • IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN
  • IMMUNOHISTOCHEMICAL STAINING FOR pCREB IN THE DORSAL ROOT GANGLION NEURONS OF VARIOUS EXPERIMENTAL MODELS OF NEUROPATHIC PAIN (en)
skos:notation
  • RIV/00216224:14110/05:00014433!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 524268
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00014433
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Transcription factors; neuropathic pain; cAMP response element binding protein; sciatic nerve; spinal nerve; rat (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [52B702EE8337]
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Dubový, Petr
  • Hradilová Svíženská, Ivana
  • Jančálek, Radim
  • Klusáková, Ilona
http://linked.open...n/vavai/riv/zamer
http://localhost/t...ganizacniJednotka
  • 14110
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