About: Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

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About: Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. (en)
Title	Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. (en)
skos:prefLabel	Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. (en)
skos:notation	RIV/00216224:14110/05:00014064!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hanesová, Mariana Pistovčáková, Jana Juřica, Jan Šulcová, Alexandra Tomandl, Josef McCaskey Hadašová, Eva Dostálek, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	521489
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00014064
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme (en)
http://linked.open.../riv/klicoveSlovo	Midazolam Cytochrome P-450 CYP3A1/2 isozyme Methamphetamine
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[69AD2DD1C0EF]
http://linked.open...i/riv/nazevZdroje	Eur J Drug Metab Pharmacokinet
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Dostálek, Miroslav Juřica, Jan Tomandl, Josef Šulcová, Alexandra Linhart, Igor Pistovčáková, Jana McCaskey Hadašová, Eva Hanesová, Mariana
http://linked.open...ain/vavai/riv/wos	000232621200008
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0378-7966
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

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