About: Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain

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About: Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Peripheral neuropathic pain has been investigated using rat peripheral nerve injury models including unilateral sciatic nerve transection or ligation, spinal nerve ligation or ventral root transection. The experimental models were utilized for the study of immunofluorescence (IF) staining for IL-1b, IL-6, TNFa and TNFaR1 in the rat DRG. Quantitative and qualitative IF changes in the DRG affected by unilateral nerve injury were compared with the contralateral ones removed from operated animals as well as naive rats. Ipsi- and contralateral DRG displayed increased IF for TNFa and TNFaR1 when compared with DRG of naive rats. The TNFa IF was increased in both DRG neurons and their satellite glial cells, while enhanced IF for TNFaR1 was observed only at the surface of satellite glial cells after various types of nerve injury. In addition, ipsilateral DRG exhibited an elevation of TNFa immunoreactivity by invaded ED-1+ macrophages. Peripheral neuropathic pain has been investigated using rat peripheral nerve injury models including unilateral sciatic nerve transection or ligation, spinal nerve ligation or ventral root transection. The experimental models were utilized for the study of immunofluorescence (IF) staining for IL-1b, IL-6, TNFa and TNFaR1 in the rat DRG. Quantitative and qualitative IF changes in the DRG affected by unilateral nerve injury were compared with the contralateral ones removed from operated animals as well as naive rats. Ipsi- and contralateral DRG displayed increased IF for TNFa and TNFaR1 when compared with DRG of naive rats. The TNFa IF was increased in both DRG neurons and their satellite glial cells, while enhanced IF for TNFaR1 was observed only at the surface of satellite glial cells after various types of nerve injury. In addition, ipsilateral DRG exhibited an elevation of TNFa immunoreactivity by invaded ED-1+ macrophages. (en)
Title	Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain (en)
skos:prefLabel	Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain (en)
skos:notation	RIV/00216224:14110/05:00012984!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA309/03/1199), Z(MSM0021622404)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jančálek, Radim Hradilová Svíženská, Ivana Pejchalová, Kateřina Dubový, Petr Klusáková, Ilona
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	525499
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00012984
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dorsal root ganglia; TNF-alpha; TNFR1 (en)
http://linked.open.../riv/klicoveSlovo	TNF-alpha TNFR1 dorsal root ganglia
http://linked.open...ontrolniKodProRIV	[21C0DF32FAB8]
http://linked.open...v/mistoKonaniAkce	Tatranská Lomnica-Stará Lesná
http://linked.open...i/riv/mistoVydani	Košice
http://linked.open...i/riv/nazevZdroje	Folia Medica Cassoviensia
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Changes of the satellite glial cells and their extracellular matrix after axotomy - conditions for the sympathetic sprouts in the spinal ganglia?
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Dubový, Petr Hradilová Svíženská, Ivana Jančálek, Radim Klusáková, Ilona Pejchalová, Kateřina
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2005-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neurobiologický ústav SAV
https://schema.org/isbn	80-7097-607-1
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Intra- and extraneuronal changes of immunofluorescence staining for inflammation-related molecules in the experimental models of peripheral neuropathic pain

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