| Attributes | Values |
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| rdf:type
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| Description
| - Mikrotubuly a aktinový cytoskelet jsou nezbytné pro mitosu a cytokinesi proliferujících živočišných buněk.Jejich blokáda cytoskeletálními inhibitory je jednou ze strategií k terapii rakoviny v lékařské onkologii. Cílem tohoto projektu bylo (i) identifikovat cytoskelet během konidiogenese u lidských houbovýhc patogenů, a (ii)testovat blokádu konidiogenese cytoskeletálními inhibitory.Získané výsledky ukázaly, zatím co výbava aktinovými strukturami se lišila u různých patogenů,mikrotubuly byly dominantními strukturami při konidiogenesi u všech studovaných organismů. Mikrotubulární toxiny blokovaly konidiogenesi účinněji než aktinové inhibitory. Výsledky ukazují na novou vedoucí funkci mikrotubulů při konidiogenesi u hub. (cs)
- Recent studies have revealed the role of cytoskeleton in the fundamental morphogenetic processes in fungi, that is, those of polar and spherical growth, and in septation during budding and fission. Actin cables are engaged in cytoplasmic transport, actin rings in cytokinesis and actin patches take part in exocytosis and endocytosis on the cell surface. Microtubules are part of the mitotic spindle and also occur in the cytoplasm, taking part in nuclear movement. Conidia - asexual spores of fungi - are relatively heterogeneous in their morphogenesis. Their cytoskeleton in the course of the conidiogenesis in fungi has not been practically studied yet. Objective of our work was to identify the cytoskeletal structures and the dynamics of cytoskeleton rearrangement in the course of conidiogenesis as targets for detection of antifungals. As electron microscopic study without immunodetection is problematic, our present work was based on immunofluorescence detection of cytoskeleton. Electron microscopy was
- Recent studies have revealed the role of cytoskeleton in the fundamental morphogenetic processes in fungi, that is, those of polar and spherical growth, and in septation during budding and fission. Actin cables are engaged in cytoplasmic transport, actin rings in cytokinesis and actin patches take part in exocytosis and endocytosis on the cell surface. Microtubules are part of the mitotic spindle and also occur in the cytoplasm, taking part in nuclear movement. Conidia - asexual spores of fungi - are relatively heterogeneous in their morphogenesis. Their cytoskeleton in the course of the conidiogenesis in fungi has not been practically studied yet. Objective of our work was to identify the cytoskeletal structures and the dynamics of cytoskeleton rearrangement in the course of conidiogenesis as targets for detection of antifungals. As electron microscopic study without immunodetection is problematic, our present work was based on immunofluorescence detection of cytoskeleton. Electron microscopy was (en)
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| Title
| - CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS
- CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS (en)
- Konidiogenese u patogenních hub: cytoskelet jako terč antifungálních látek (cs)
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| skos:prefLabel
| - CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS
- CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS (en)
- Konidiogenese u patogenních hub: cytoskelet jako terč antifungálních látek (cs)
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| skos:notation
| - RIV/00216224:14110/04:00011438!RIV/2005/GA0/141105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00011438
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - conidiogenesis - cytoskeleton- human pathogenic fungi - inhibitors of actin and microtubules (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
| - 8th Asia-Pacific Conference on Electron Microscopy (8APEM)
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Kopecká, Marie
- Yamaguchi, Masashi
- Svoboda, Augustin
- Gabriel, Miroslav
- Takeo, Kanji
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Medical University Kanazawa, Japan
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| http://localhost/t...ganizacniJednotka
| |
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