About: Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats

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About: Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activities of animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/explorat The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activities of animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/explorat (en) Výsledky ukázaly na významnou roli 5-HT1 receptorového systému v regulacích lokomočně-pátrací aktivity potkanů. (cs)
Title	Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats (en) Porovnání úlohy receptorů 5-HT1 a 5-HT2 v regulaci lokomočně-pátracího chování potaknů (cs)
skos:prefLabel	Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats (en) Porovnání úlohy receptorů 5-HT1 a 5-HT2 v regulaci lokomočně-pátracího chování potaknů (cs)
skos:notation	RIV/00216224:14110/04:00010698!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany	46-48
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP305/02/D130), Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Nováková, Jana Šulcová, Alexandra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	558325
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/04:00010698
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats (en)
http://linked.open.../riv/klicoveSlovo	serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats
http://linked.open...odStatuVydavatele	IT - Italská republika
http://linked.open...ontrolniKodProRIV	[305FA6AFAE5D]
http://linked.open...i/riv/nazevZdroje	Homeostasis
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional role of serotonin 5-HT2 receptor subtype in development of methamphetamine dependence
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Nováková, Jana Šulcová, Alexandra
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0960-7560
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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