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rdf:type
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Description
| - K ovlivnění přirozených regulačních mechanizmů které kontrolují metabolismus, proliferaci a migraci nádorových buněk, biologická léčba dává přednost nízkomolekulárním preparátům, makromolekulám a efektorům typu buněčné imunity. Výzkum se momentálně přednostně zaměřuje na možnost inhibice intracelulárních domén EGF receptorů. V článku autoři diskutují o různých možnostech ovlvnění EGFR a jejich aplikaci v klinické praxi. (cs)
- To influence natural regulatory mechnisms, which control the metabolism, proliferation and migration of tumour cells, biological therapy resorts to low-molecular preparations, macromolecules and cellular immune-type effectors. Today we have primarily information on the influencing of the epidemal growth factor receptor - EGFR.Research concentrates above all on the possibility of inhibiting the intracellular domains of the EGF receptor that has a tyrosinekinase activity. This oncological tratment targes intracellular mechanism of the transfer ot the signal taht calls forth changes in the proliferation activity of tunour cells. In their paper the authors discuss various possibilities of influencing EGFR and their appliction in clinical practice.
- To influence natural regulatory mechnisms, which control the metabolism, proliferation and migration of tumour cells, biological therapy resorts to low-molecular preparations, macromolecules and cellular immune-type effectors. Today we have primarily information on the influencing of the epidemal growth factor receptor - EGFR.Research concentrates above all on the possibility of inhibiting the intracellular domains of the EGF receptor that has a tyrosinekinase activity. This oncological tratment targes intracellular mechanism of the transfer ot the signal taht calls forth changes in the proliferation activity of tunour cells. In their paper the authors discuss various possibilities of influencing EGFR and their appliction in clinical practice. (en)
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Title
| - Ovlivnění receptorů pro epidermální růstový faktor - nové vyhlídky v léčbě nemalobuněčného bronchogenního karcinomu (cs)
- Influencing the epidermal growth factor receptor - new prospects in the treatment of non-small-cell bronchogenic carcinoma
- Influencing the epidermal growth factor receptor - new prospects in the treatment of non-small-cell bronchogenic carcinoma (en)
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skos:prefLabel
| - Ovlivnění receptorů pro epidermální růstový faktor - nové vyhlídky v léčbě nemalobuněčného bronchogenního karcinomu (cs)
- Influencing the epidermal growth factor receptor - new prospects in the treatment of non-small-cell bronchogenic carcinoma
- Influencing the epidermal growth factor receptor - new prospects in the treatment of non-small-cell bronchogenic carcinoma (en)
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skos:notation
| - RIV/00216224:14110/04:00010300!RIV08-MSM-14110___
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00010300
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - non-small-cell bronchogenic carcinomua; oncological therpy; epidermal growth factor receptor (EGFR); EGFR tyrosinekinase inhibitors; gefitinib (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Studia Pneumologica et Phthiseologica
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Babičková, Lenka
- Skřičková, Jana
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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