About: The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour     Goto   Sponge   NotDistinct   Permalink

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Description
  • Premedikace opakovým podáním agonisty kanabinoidních CB2 receptorů, JWH 015, nevyvolala zkříženou sensitizaci k antiagresivním účinkům metamfetaminu u myší. (cs)
  • The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.
  • The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study. (en)
Title
  • Vliv agonsity kanabinoidních CB2 receptotů na rozvoj sensitizace k metafetaminovým účinkům na agonistické chování myší (cs)
  • The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
  • The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour (en)
skos:prefLabel
  • Vliv agonsity kanabinoidních CB2 receptotů na rozvoj sensitizace k metafetaminovým účinkům na agonistické chování myší (cs)
  • The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
  • The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour (en)
skos:notation
  • RIV/00216224:14110/04:00009923!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 54-54
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • Suppl. 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 567816
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00009923
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • behavioural sensitization; CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [A6D65BE9AA9E]
http://linked.open...i/riv/nazevZdroje
  • Psychiatrie
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 8
http://linked.open...iv/tvurceVysledku
  • Landa, Leoš
  • Šulcová, Alexandra
  • Šlais, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-7579
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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