About: Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus     Goto   Sponge   NotDistinct   Permalink

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Description
  • Nezjistili jsme asociaci tri nove identifikovanych polymorfizmu v promotorove oblasti genu pro TIMP-3 (-899T/A, -915A/G a ĄV1296T/C) nejsou asociovany s proliferativni diabetickou retinopatii. (cs)
  • Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms(-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjec
  • Purpose: Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a member of the TIMP family of proteins, playing a significant role in the control of extracellular matrix remodelling. TIMP-3 might play a role in regulation of retinal neovascularization during progression of diabetic retinopathy. Recently, three novel polymorphisms(-899T/A, -915A/G and ĄV1296T/C) in the promoter region of the TIMP-3 gene were identified. The aim of the study was to investigate a possible association of these polymorphisms with proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM). Methods: Genotypes were detected by polymerase chain reaction and subsequent restriction with specific endonucleases. Allele frequencies were determined in an association study comprising three groups of subjects (n=371). Results: Linkage disequilibrium was found among the three polymorphisms. Allele frequencies did not differ between neither T2DM+PDR and T2DM non-PDR subjects nor between all T2DM versus non-diabetic subjec (en)
Title
  • Tri nove identifikovane polymorfizmy v promotorove oblasti genu pro TIMP-3 nejsou asociovany s proliferativni diabetickou retinopatii (cs)
  • Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus
  • Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus (en)
skos:prefLabel
  • Tri nove identifikovane polymorfizmy v promotorove oblasti genu pro TIMP-3 nejsou asociovany s proliferativni diabetickou retinopatii (cs)
  • Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus
  • Three novel polymorphisms in the promoter region of the TIMP-3 gene are not associated with proliferative diabetic retinopathy in type 2 diabetes mellitus (en)
skos:notation
  • RIV/00216224:14110/03:00008773!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 630986
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/03:00008773
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • diabetes; retinopathy; TIMP-3 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [2FBD480D34DB]
http://linked.open...i/riv/nazevZdroje
  • Current Eye Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Kolář, Petr
  • Kaňková, Kateřina
  • Beránek, Michal
  • Tschöplová, Svatava
  • Vácha, Jiří
http://linked.open...ain/vavai/riv/wos
  • 000185227300004
http://linked.open...n/vavai/riv/zamer
issn
  • 0271-3683
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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