About: Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects     Goto   Sponge   NotDistinct   Permalink

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Description
  • Článek se zabývá nepříznivými účinky Paroxetinu na indukované konverze cytochormu P450 2D6 fenotypu (cs)
  • The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype.
  • The paper is focused on a comparison of the distribution of side-effects of treatment with paroxetine within a group of 30 patients genotyped ane phenotyped for their CYP2D6 metabolic status.Genotyping procedure showed that the patient group did not include any individual with poor metabolizer (PM) genotype,on the other hand,most patients (24) were classified as PMs by virtue of their phenotype,which suggests that a conversion to the poor metabolic phenotype occured,probably as a consequence of a long-term administration of the strong CYP2D6 inhibitor paroxetine.As to the occurence of common adverse effects,no marked difference between subjects converted into to PM group and those who had no history of such conversion was found.A significantly higher incidence of sexual dysfunction was,nevertheless,recorded in patients with the PM phenotype. (en)
Title
  • Paroxetin-indukovaná konverze cytochormu P450 2D6 fenotypu a nepříznivé účinky (cs)
  • Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects
  • Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects (en)
skos:prefLabel
  • Paroxetin-indukovaná konverze cytochormu P450 2D6 fenotypu a nepříznivé účinky (cs)
  • Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects
  • Paroxetine-Induced Conversion of Cytochrome P450 2D6 Phenotype and Occurence of Adverse Effects (en)
skos:notation
  • RIV/00216224:14110/03:00008770!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 620383
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/03:00008770
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CYP2D6; phenotype; paroxetine; depression; adverse effects (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [B18B2CF75EDE]
http://linked.open...i/riv/nazevZdroje
  • General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 22
http://linked.open...iv/tvurceVysledku
  • Žourková, Alexandra
  • McCaskey Hadašová, Eva
http://linked.open...ain/vavai/riv/wos
  • 000183539200009
http://linked.open...n/vavai/riv/zamer
issn
  • 0231-5882
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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