About: Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus

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About: Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prehledny clanekshrnuje poznatky o roli geneticke variabilty v systemech zajistujicich receptory-zprostredkovanou a enzymatickou obranu proti glykaci v patogenezi pozdnich komplikaci diabetu mellitus. (cs) Diabetes mellitus is the most common metabolic disease with late complications due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for diabetic cell damage. Variable functional capacity of detoxifying systems could contribute to different susceptibility to develop complications. Identification of genetic variants responsible for modulating relevant intermediate phenotype in diabetic milieu could help to define individual risk-profile and to modify therapeutic strategy accordingly. Diabetes mellitus is the most common metabolic disease with late complications due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for diabetic cell damage. Variable functional capacity of detoxifying systems could contribute to different susceptibility to develop complications. Identification of genetic variants responsible for modulating relevant intermediate phenotype in diabetic milieu could help to define individual risk-profile and to modify therapeutic strategy accordingly. (en)
Title	Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus (en) Role geneticke variabilty v systemech zajistujicich receptory-zprostredkovanou a enzymatickou obranu proti glykaci v patogenezi pozdnich komplikaci diabetu mellitus (cs)
skos:prefLabel	Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus Role of genetic variability in systems of receptor-mediated and enzymatic defence against glycation in long-term consequences of diabetes mellitus (en) Role geneticke variabilty v systemech zajistujicich receptory-zprostredkovanou a enzymatickou obranu proti glykaci v patogenezi pozdnich komplikaci diabetu mellitus (cs)
skos:notation	RIV/00216224:14110/03:00008104!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP303/02/D127), Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Kaňková, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	625886
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/03:00008104
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	diabetes mellitus; complications; polymorphism; glycation; AGE; methylglyoxal (en)
http://linked.open.../riv/klicoveSlovo	methylglyoxal AGE complications diabetes mellitus - insulin resistance - ethiopathogenesis - diagnostic criteria - late complications - advanced age - treatment polymorphism glycation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[00A0F7D8D126]
http://linked.open...i/riv/nazevZdroje	Biochemical Society Transactions
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...vavai/riv/projekt	Relationship between genetic variability of antioxidant system and late complications of diabetes mellitus
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Kaňková, Kateřina
http://linked.open...ain/vavai/riv/wos	000187289000060
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	0300-5127
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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