| Attributes | Values |
|---|
| rdf:type
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| Description
| - Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Rats with bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambulation)
- Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Rats with bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambulation) (en)
- Amisulpride is a benzamide derivative with unique neurochemical and psychopharmacological profiles, characterized by a preferential blockade of dopamine D2/D3 presynaptic autoreceptors in the limbic structures (Schoemaker et al., 1997) after low dosing and antagonism at postsynaptic D receptors after high doses (Coukell et al., 1996). There are clinical reports available about both antidepressant (in low dopaminergic doses) and antipsychotic (in high antidopaminergic doses) effects of amisulpride. Rats with bilateral lesion of the olfactory bulb (OB rats) which are used as an animal model resembling behavioural and endocrine changes found in human depression were used in the present study to examine potential antidepressant effects of amisulpride. OB rats show significant increase in ambulation and rearing scores in "open-field" tests (Leonard, 1983) which is suppressed by clinically used antidepressants. Thus, both acute and repeated amisulpride treatment on locomotor behaviour (ambulation) (cs)
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| Title
| - Antidepressant-like effects of amisulpride in bubectomized male rats
- Antidepressant-like effects of amisulpride in bubectomized male rats (en)
- Antidepressant-like effects of amisulpride in bubectomized male rats (cs)
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| skos:prefLabel
| - Antidepressant-like effects of amisulpride in bubectomized male rats
- Antidepressant-like effects of amisulpride in bubectomized male rats (en)
- Antidepressant-like effects of amisulpride in bubectomized male rats (cs)
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| skos:notation
| - RIV/00216224:14110/02:00007505!RIV08-MSM-14110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/02:00007505
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - antidepressant; olfactory bulbectomy; amisulpride; rat (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...v/mistoKonaniAkce
| - June 1-5, 2002 Častá, Slovakia
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| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| - Neuroscience in the Third Millennium, X. International Congress of the Czech and Slovak Neurochemical Society
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Šulcová, Alexandra
- Pistovčáková, Jana
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| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
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| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Czech and Slovak Neurochemical Society
|
| http://localhost/t...ganizacniJednotka
| |
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